Sofosbuvir + Ribavirin for 12 or 16 Weeks in Treatment Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection (FUSION)

PHASE3CompletedINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

June 30, 2012

Primary Completion Date

February 28, 2013

Study Completion Date

May 31, 2013

Conditions
Chronic Hepatitis C
Interventions
DRUG

SOF

Sofosbuvir (SOF) 400 mg tablet was administered orally once daily.

DRUG

RBV

Ribavirin (RBV) tablets was administered orally in a divided daily dose according to package insert weight-based dosing recommendations (\< 75kg = 1000 mg and ≥ 75 kg = 1200 mg).

DRUG

Placebo to match SOF

Placebo to match SOF was administered orally once daily.

DRUG

Placebo to match RBV

Placebo to match RBV was administered orally twice daily.

Trial Locations (67)

1640

Auckland Clinical Studies Limited, Auckland

8011

Christchurch Hospital, Christchurch

10029

Mount Sinai School of Medicine, New York

13903

Binghamton Gastroenterology Associates, Binghamton

19104

University of Pennsylvania, Philadelphia

20009

Whitman Walker Clinic, Washington D.C.

21093

Johns Hopkins University, Lutherville

22031

Metropolitan Research, Fairfax

22042

Inova Fairfax Hospital Center for Liver Diseases, Falls Church

23226

Bon Secours St. Mary's Hospital of Richmond, Inc., Richmond

23502

Digestive and Liver Disease Specialists, Norfolk

27103

Digestive Health Specialists, PA, Winston-Salem

27710

Duke University Medical Center, Durham

28801

Asheville Gastroenterology Associates, P.A., Asheville

30060

Gastrointestinal Specialists of Georgia, PC, Marietta

30309

Digestive Healthcare of Georgia, Atlanta

32256

Borland-Groover Clinic Baptist, Jacksonville

32806

Internal Medicine Specialists, Orlando

33136

University of Miami, Miami

33414

South Florida Center of Gastroenterology, P.A., Wellington

34653

Advanced Research Institute, New Port Richey

37211

Nashville Gastrointestinal Specialists, Inc, Nashville

38138

Gastro One, Germantown

42101

Graves-Gilbert Clinic, Bowling Green

46237

Indianapolis Gastroenterology Research Foundation, Indianapolis

48377

Henry Ford Health System, Novi

55414

Minnesota Gastroenterology, P.A., Minneapolis

64131

Kansas City Gastroenterology and Hepatology, Kansas City

70809

Gastroenterology Associates, LLC, Baton Rouge

75219

Southwest Infectious Disease Clinical Research, Inc., Dallas

76012

Texas Clinical Research Institute, LLC, Arlington

78215

Alamo Medical Research, San Antonio

80045

University of Colorado, Aurora

80113

South Denver Gastroenterology, PC, Englewood

87505

Southwest C.A.R.E. Center, Santa Fe

90027

Kaiser Permanente, Los Angeles

90036

Peter J. Ruane, MD, Inc., Los Angeles

90069

Anthony Mills MD, Inc., Los Angeles

92103

UCSD Antiviral Research Center, San Diego

92118

SCTI Research Foundation, Coronado

92123

Medical Associates Research Group, Inc., San Diego

92154

Kaiser Permanente, San Diego

94115

Quest Clinical Research, San Francisco

98101

Virginia Mason Medical Center, Seattle

32610-0277

University of Florida, Gainesville

32803-1851

Orlando Immunology Center (ACH), Orlando

02114-2696

Massachusetts General Hospital, Boston

02115

Beth Israel Deaconess Medical Center, Boston

01105

The Research Institute, Springfield

08009

Comprehensive Clinical Research, Berlin

08844

ID Care, Hillsborough

02905

University Gastroenterology, Providence

02906

The Miriam Hospital, Providence

T2N 4Z6

University of Calgary, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

T6G 2X8

University of Alberta Hospital, Edmonton

V5Z 1M9

Gordon & Leslie Diamond Health Care Centre, Vancouver

V6Z 2C9

University of British Columbia, Vancouver

V6Z 2K5

(G.I.R.I.) Gastrointestinal Research Institute, Vancouver

R3E 3P4

University of Manitoba Health Sciences Center, Winnipeg

K1H 8L6

The Ottawa Hospital, Ottawa

M5G 1X5

Mount Sinai Hospital, Toronto

M5T 2S8

Toronto Western Hospital, Toronto

M6H 3M1

Toronto Liver Centre, Toronto

H2X 3J4

Hopital St. Luc, Montreal

00909-1711

Clinical Research Puerto Rico Inc, San Juan

00927

Fundacion De Investigacion De Diego, San Juan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY

NCT01604850 - Sofosbuvir + Ribavirin for 12 or 16 Weeks in Treatment Experienced Subjects With Chronic Genotype 2 or 3 HCV Infection (FUSION) | Biotech Hunter | Biotech Hunter