A Study to Evaluate the Efficacy and Safety of Ibrutinib, in Patients With Mantle Cell Lymphoma Who Progress After Bortezomib Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

August 31, 2012

Primary Completion Date

May 31, 2015

Study Completion Date

May 31, 2015

Conditions
Mantle Cell Lymphoma
Interventions
DRUG

Ibrutinib

Type=exact number, unit=mg, number=560, form=capsule, route=oral use. 560 mg oral ibrutinib is to be administered once daily continuously until disease progression, unacceptable toxicity, or study end, whichever occurs first. Doses can be held or reduced based on the severity of and the recovery from side effects of the study drug.

Trial Locations (56)

Unknown

La Jolla

Los Angeles

Stanford

Norwalk

Jacksonville

Chicago

Peoria

Goshen

Iowa City

Sioux City

Westwood

Lexington

Louisville

Metairie

Baltimore

Boston

Worcester

Ann Arbor

Detroit

Jefferson City

St Louis

Omaha

Hackensack

New York

Syracuse

Watertown

Nashville

Houston

Burlington

Charlottesville

Morgantown

Madison

Bruges

Ghent

Grenoble

Mulhouse

Nantes

Pessac

Vandœuvre-lès-Nancy

Afula

Beer Yaakov

Hadera

Haifa

Nahariya

Petah Tikva

Ramat Gan

Chorzów

Lodz

San Juan

Nizhny Novgorod

Rostov-on-Don

Saint Petersburg

Barcelona

Salamanca

London

Plymouth

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pharmacyclics LLC.

INDUSTRY

lead

Janssen Research & Development, LLC

INDUSTRY