368
Participants
Start Date
June 30, 2012
Primary Completion Date
September 11, 2020
Study Completion Date
September 11, 2020
Haploidentical Bone Marrow Transplant
"The conditioning regimen consists of:~Fludarabine (Flu)30 mg/m2 IV Days -6, -5, -4, -3, -2 Cyclophosphamide (Cy) 14.5 mg/kg IV Days -6, -5 Total body irradiation (TBI) 200cGy Day -1~The GVHD prophylaxis regimen consists of:~Cy 50 mg/kg IV Days 3, 4 Tacrolimus (IV or PO) beginning Day 5 Mycophenolate mofetil (MMF) 15 mg/kg po three times a day, maximum dose 1 g po TID beginning Day 5 until Day 35"
Double Umbilical Cord Blood Transplant
"The preparative regimen consists of:~Fludarabine 40 mg/m2 IV Days -6, -5, -4,-3, -2 Cyclophosphamide 50 mg/kg IV Day -6 Total Body Irradiation (TBI) 200 cGy Day -1 for patients who have received cytotoxic chemotherapy within the 3 months of enrollment or an autologous transplant within 24 months of enrollment or 300 cGy Day -1 for patients who have not received cytotoxic chemotherapy within the 3 months of enrollment and who have not received an autologous transplant within 24 months of enrollment.~The GVHD prophylaxis regimen consists of:~Cyclosporine beginning Day -3 with dose adjusted to maintain a trough level of 200-400 ng/mL.~Mycophenolate mofetil (MMF) 15 mg/kg po three times a day, maximum dose 1 g po TID beginning Day -3 until Day 35"
Mt. Sinai Medical Center, New York
Memorial Sloan Kettering Cancer Center, New York
Roswell Park Cancer Center, Buffalo
University of Rochester Medical Center, Rochester
Penn State College of Medicine - The Milton S. Hershey Medical Center, Hershey
University of Pennsylvania Cancer Center, Philadelphia
Johns Hopkins University, Baltimore
Virginia Commonwealth University, Richmond
Duke University Medical Center, Durham
Medical University of South Carolina, Charleston
Emory University, Atlanta
BMT Program at Northside Hospital, Atlanta
Florida Hospital Cancer Institute, Orlando
University of Alabama at Birmingham, Birmingham
Vanderbilt University Medical Center, Nashville
Ohio State / Arthur G. James Cancer Hospital, Columbus
Cleveland Clinic Foundation, Cleveland
Jewish Hospital BMT Program, Cincinnati
University of Michigan Medical Center, Ann Arbor
Karmanos Cancer Institute/BMT, Detroit
Medical College of Wisconsin, Milwaukee
Univeristy of Minnesota, Minneapolis
Mayo Clinic Rochester, Rochester
University of Kansas Hospital, Kansas City
University of Oklahoma Medical Center, Oklahoma City
Univesity of Texas, MD Anderson CRC, Houston
Texas Transplant Institute, San Antonio
Arizona Cancer Center, Phoenix
University of California at Los Angeles, Los Angeles
Stanford Hospital and Clinics, Stanford
City of Hope National Medical Center, Duarte
University of Florida College of Medicine (Shands), Gainesville
DFCI Massachustts General Hospital, Boston
DFCI Brigham & Women's Hospital, Boston
Stony Brook University Medical Center, Stony Brook
University of North Carolina Hospital at Chapel Hill, Chapel Hill
University Hospitals of Cleveland, Case Western, Cleveland
Fred Hutchinson Cancer Research Center, Seattle
West Virginia University, Morgantown
National Heart, Lung, and Blood Institute (NHLBI)
NIH
National Cancer Institute (NCI)
NIH
Blood and Marrow Transplant Clinical Trials Network
NETWORK
National Marrow Donor Program
OTHER
Medical College of Wisconsin
OTHER