Magnetic Seizure Therapy (MST) for Treatment Resistant Depression, Schizophrenia, and Obsessive Compulsive Disorder

NACompletedINTERVENTIONAL
Enrollment

224

Participants

Timeline

Start Date

February 29, 2012

Primary Completion Date

June 30, 2019

Study Completion Date

June 30, 2019

Conditions
Depressive DisorderSchizophreniaSchizoaffective DisorderObsessive-Compulsive Disorder
Interventions
DEVICE

Magnetic Seizure Therapy (MagPro MST)

100% machine output at between 25 and 100 Hz, with coil directed over frontal or vertex brain regions, until adequate seizure achieved. Six treatment sessions, at a frequency of two or three times per week will be administered. If subjects fail to achieve the pre-defined criteria of remission at that point, the dose will be increased to the maximal stimulator output and 3 additional treatment sessions will be provided. This will be repeated a total of 5 times (i.e., maximum treatment number is 24). 24 treatments is typically longer that a conventional ECT treatment course. However, evidence does suggest that longer treatment courses may be needed with MST, particularly in more treatment resistant psychiatric conditions such as OCD and schizophrenia.

Trial Locations (1)

M6J 1H4

Centre for Addiction and Mental Health, Toronto

All Listed Sponsors
collaborator

University Health Network, Toronto

OTHER

lead

Centre for Addiction and Mental Health

OTHER

NCT01596608 - Magnetic Seizure Therapy (MST) for Treatment Resistant Depression, Schizophrenia, and Obsessive Compulsive Disorder | Biotech Hunter | Biotech Hunter