29
Participants
Start Date
October 31, 2012
Primary Completion Date
December 30, 2017
Study Completion Date
December 30, 2017
Inhaled Vancomycin
On Days 1-28, subjects will receive nebulized Vancomycin. This will be supplied as a 250 mg solution to be nebulized two times a day for 28 days in 5cc sterile water. Patients will use a Pari Sprint nebulizer and Pari Vios compressor as the delivery system.
Placebo (Sterile Water)
On Days 1-28, subjects will receive 5cc of a nebulized Placebo (Sterile water) twice a day. This is a taste (quinine 0.1mg/mL) matched nebulized placebo (sterile water). Patients will use a Pari Sprint nebulizer and Pari Vios compressor as the delivery system.
Rifampin
"Oral Rifampin by mouth for 28 days~1. \>45 kg: 600 mg by mouth daily~2. 35-45 kg : 450 mg by mouth daily~3. 25-34.9 kg: 300 mg by mouth daily"
Trimethoprim/Sulfamethoxazole (TMP/SMX)
"Oral trimethoprim/sulfamethoxazole (DS-160/800)~1. \>45 kg: two DS tablets twice a day by mouth (320/1600)~2. 25-45 kg: one DS tablet twice a day by mouth (160/800)"
Doxycycline
"If sulfa intolerant or TMP/SMX Resistant, use instead oral doxycycline~1. \>45 kg: 100 mg by mouth twice a day~2. 35-45 kg : 75 mg by mouth twice a day iii. 25-34.9 kg: 50 mg by mouth twice a day"
Mupirocin Intranasal Creme
Mupirocin 2% intranasal creme: half of single use tube applied into each nostril twice a day for 5 days.
4% chlorhexidine gluconate liquid skin cleanser
Hibiclens 15cc liquid skin cleanser packets (4% chlorhexidine gluconate): use three packets once weekly for four weeks in the shower from the neck to toes, with attention on the axilla, groin, and buttocks.
Johns Hopkins University School of Medicine, Baltimore
Rainbow Babies and Children's Hospital, Cleveland
Case Western Reserve University
OTHER
Cystic Fibrosis Foundation
OTHER
Johns Hopkins University
OTHER