4,786
Participants
Start Date
April 30, 2013
Primary Completion Date
April 15, 2019
Study Completion Date
October 30, 2019
Methotrexate
Tablet, Oral, Target dose 15-20 mg weekly plus 1.0 mg folic acid 6 days/week
Placebo
Tablet, Oral, weekly plus 1.0 mg folic acid 6 days/week
Chinatown Cardiology, PC, New York
Weill Cornell Medical College and NY Presbyterian, New York
Mount Sinai School of Medicine, New York
Novel Research of New York, LLC, The Bronx
Montefiore Medical Center, The Bronx
NYU Hudson Valley Cardiology, Cortlandt Manor
Long Island Jewish Medical Center, New Hyde Park
Brown - SUNY Downstate Medical Center, Brooklyn
NYHQ, Flushing
Jamaica Hospital Medical Center, Jamaica
Long Island Heart Associates, Mineola
Winthrop University Hospital, Mineola
Queens Long Island Medical Group, New Hyde Park
DiGiovanna Institute for Medical Education and Research, North Massapequa
Albany Medical College, Albany
Albany Stratton VA Medical Center, Albany
Cardiology Associates of Schenectady, Schenectady
Champlain Valley Physician Hospital, Plattsburgh
Bassett Healthcare Network, Cooperstown
Buffalo Heart Group, Buffalo
Pish Medical Associates, Inc., Uniontown
Saint Vincent Consultants in Cardiovascular Diseases, LLC, Erie
Altoona Center for Clinical Research, Duncansville
Spirit Physician Services, Inc, Camp Hill
Pinnacle Health Cardiovascular Institute, Harrisburg
The Chambersburg Hospital, Chambersburg
Heart Specialists of Lancaster County, Ephrata
St. Luke's University Hospital, Bethlehem
Lehigh Valley Family Practice, Whitehall
Wilkes-Barre VA Medical Center, Wilkes-Barre
Central Bucks Cardiology, Doylestown
Lehigh Valley Health Services, Sellersville
Center for Clinical Res. Abington Health, Abington
Renu-Ca Research Institute, Lower Bucks Hospital, Bristol
Main Line Health Center, Broomall, Broomall
George Isajiw, MD, Lansdowne
Feasterville Family Healthcare Center, Feasterville
Bucks County Clinical Research, Morrisville
Drexel University College of Medicine, Philadelphia
Hospital of the University of Pennsylvania, Philadelphia
Christiana Care Health System, Glen Mills
Cardiology Physicians/Red Clay Research, Newark
Boisey Barnes MD, PC, Washington D.C.
GWU Medical Faculty Associatin, Inc., Washington D.C.
Virginia Cardiovascular Associates, Manassas
Manassas Clinical Research Center, Manassas
St. Mary's Medical Center, Charlotte Hall
Shah Associates, MD, LLC, Prince Frederick
Calvert Memorial Hospital, Clinton
IRC Clinics, Towson
Sinai Center for Thrombosis Research, Baltimore
Peninsula Cardiology Associates, Salisbury
Burke Internal Medicine & Research, Burke
Seven Corners Medical Research Center, Falls Church
Cardinal Internal Medicine Associates, Woodbridge
Tucker Cardiology Associates, P.C., Mechanicsville
Sentara Norfolk General Hospital, Norfolk
TPMG Clinical Research, Newport News
Hampton Family Practice Research, Hampton
Tidewater Physicians Multispecialty Group, Hampton
Tidewater Physicians Multispecialty Group, Yorktown
Roanoke Heart Institute PLC, Roanoke
Sanford Cardiology, Sanford
Boice Willis Clinic, Rocky Mount
Eastern Cardiology, Greenville
Natalie A. Doyle, MD, PA, Wilson
Eastern Carolina Cardiovascular, PA, Elizabeth City
Lake Shore Clinical Research, LLC., Mooresville
Metrolina Internal Medicine, Charlotte
Gaffney Health Services, Charlotte
Carolinas Research Center, Charlotte
Carteret Medical Group, Morehead City
Eastern Nephrology Associates, PLLC, New Bern
Northside Clinical Research, Lenoir
Cardiology Associates of Carolinas, PA, Morganton
Clinical Study Center of Asheville, Asheville
Miller - SC Internal Medicine Associates.: Irmo, Irmo
South Carolina Heart Center, Columbia
Amistad Research Center, LLC, Columbia
Fusion Clinical Research of Spartanburg, Spartanburg
Palmetto Research Center, LLC, Spartanburg
Inlet Cardiopulmonary & Associates, Pawleys Island
Charlotte Hearts, Old Point Station
Herman Clinical Research, LLC, Suwanee
Atlanta Veterans Affairs Medical Center, Atlanta
Atlanta Heart Specialists, LLC, Cumming
Atlanta Vanguard Medical Associates, Smyrna
Atlanta Heart Specialists, LLC, Tucker
Infinite Clinical Trials, Riverdale
Laureate Medical Group at Northside, Atlanta
Synergy Therapeutic Partners, Atlanta
Albert F. Johary MD, PC, Dunwoody
Northside Hospital, Atlanta
Cardiology Associates of Vidalia, P.C., Vidalia
Athens Regional Medical Center, Athens
Heart and Rhythm Specialists, Dalton
Daytona Heart Group, Daytona Beach
The Cardiac and Vascular Institute, Gainesville
University of Florida, Gainesville
Daytona Heart Group, DeLand
Lake Internal Medicine Assocaties, Eustis
Orlando Healthy Heart Institute, Orlando
Qway Research, Hialeah
State of the Art Research, Hialeah
Healing Touch C&C Research, Hialeah
Luzmed Clinical Research Institute, Hialeah
Viviana Perez MD Research & Cosmetics, Hialeah
Elite Cardiac Research Center LLC, Hialeah
Nova Clinical Research Clinic, Hialeah
Lakes Research, LLC, Miami Lakes
Veritas Research Corp., Miami Lakes
Best Quality Research, Inc., Hialeah
South Florida Research Solutions, LLC, Hollywood
Broward Research Center, Pembroke Pines
Pioneer Clinical Research, Pembroke Pines
John Gutleber Medical Research Office, Homestead
Medical Research Center of Florida, Miami
Infinite Clinical Research, Doral
LG Diagnostics, Inc., Miami
St. Paul Medical Research Center, Inc., Miami
Gonzalez MD & Aswad MD Health Ser, Coral Gables
Team Medical Research, Miami
Paradise Clinical Research, LLC, Miami
GAD Research Center, Miami
Innovation Research Institute, Inc., Miami
Sanitas Research, Miami
American Research Institute, Inc., Cutler Bay
Segui - Med Care Research, Miami
International Research Partners, LLC, Doral
Ocean Blue Medical Research Center, Miami Springs
Lenus Research & Medical Group, Sweetwater
South Florida Research Group, LLC, Miami
Vista Health Research, LLC, Miami
Medical Research Institute at Doral, Inc., Doral
Pianko - Aventura Research Center, LLC, Aventura
D De La Vega MD Research Group, Miami
Sandoval - Broward Research Center, Pembroke Pines
Invesclinic, Fort Lauderdale
DBC Research, Tamarac
Palm Beach Gardens Research Center, LLC, Palm Beach Gardens
North Ridge Heart Associates, Boca Raton
Cardiovascular Medical Associates of Palm Beach, Jupiter
Seidman Clinical Trials, Delray Beach
Steven Cohen MD, Delray Beach
Gupta - Premier Heart and Vascular Center, Wesley Chapel
Bay Area Heart Center: 49th Street, St. Petersburg
Bay Area Heart Center: 7th Avenue, St. Petersburg
St. Francis Medical Institute, Clearwater
Primary Care Associates, Fort Myers
Lee Physician Group, Fort Myers
Southwest Florida Research, LLC, Naples
Asclepes Research Centers, Weeki Wachee
Hope Clinical Research, Kissimmee
SIH Research, LLC, Kissimmee
University of Alabama at Birmingham, Birmingham
Saadat Ansari MD LLC, Huntsville
Appalachian Research Associates, Fort Payne
Avant Research Associates, LLC, Guntersville
University of South Alabama: Division of Clinical Research, Mobile
Clinical Research Center Meharry Medical College, Nashville
Parkway Medical Group, Fayetteville
New Phase Research & Development, Chattanooga
New Phase Research & Development, Knoxville
Cardiovascular Research of Knoxville, Knoxville
Ramanathan - VAMC Memphis, Memphis
Stern Cardiovascular Foundation, Inc., Germantown
Kore Cardiovascular Research Institutue, Jackson
Stern Cardiovascular Foundation, Inc., Southaven
David M. Headley M.D. PA Planters Clinic, Port Gibson
University of MS Medical Center, Jackson
Gulfside Clinical Research, LLC, Gulfport
Robley Rex VAMC, Louisville
Stoddard - University of Louisville, Louisville
Bays - L-MARC Research Center, Louisville
University of Kentucky, Lexington
Research Integrity LLC, Owensboro
Mount Carmel Clinical Cardiovascular Care, Westerville
Colonnade Medical Group, Lancaster
Optimed Research, LTD, Columbus
Comprehensive Heart Care, Inc., Toledo
Premier Physicians, Westlake
Cleveland Clinic, Cleveland
Akron General Medical Center, Akron
Wooster Heart Group, Wooster
Diabetes and Endocrinology Associates of Stark Cit, Canton
Middletown Cardiovascular Associates, Middletown
The Lindner Research Center, Cincinnati
Dayton Heart Center, Dayton
Dayton Veteran Affairs Medical Center, Dayton
Ohio University Heritage College of Osteopathic Medicine, Athens
Krannert Institute Of Cardiology, Indianapolis
Community Hospital South, Indianapolis
Indiana Heart Physicians, Indianapolis
Cardiospecialists, LTD, Dyer
Medical Consultants, PC, Muncie
Martin - Martin Family Practice and Research, Evansville
Beaumont Health Center, Royal Oak
Garden City Hospital, Garden City
John D. Dingell Veterans Affairs Medical Center, Detroit
Trace Research Group at Wayne State University, Detroit
Henry Ford Hospital, Detroit
National Clinical LLC, Hamtramck
Academic Cardiology Associates PC, Rochester Hills
Genesys Regional Medical Center, Grand Blanc
Flint Clinical Research, Flint
Apex Medical Research MI, Inc., Flint
Covenant Medical Center, Inc., Saginaw
Mid-Michigan Heart & Vascular Center, Saginaw
Endeavor Medical Research, Alpena
Iowa Heart Center, West Des Moines
Columbia St. Mary's, Milwaukee
Aurora St. Luke's Medical Center, Milwaukee
Dean Foundation, Madison
University Of Wisconsin, Madison
Cardiology Associates of Bellin Health, Green Bay
Marshfield Clinic, Marshfield
United Heart and Vascular Clinic, Saint Paul
Centra Care Heart & Vascular Center at St. Cloud Hospital, Saint Cloud
Altru Health System Rehab Center, Grand Forks
Great Falls Clinic Clinical Research Deptartment, Great Falls
Cone - Montana Medical Research, Missoula
Northwest Heart Clinical Research, Arlington Heights
Captain James A. Lovell Federal Health, North Chicago
Specialty Physicians of Illinois, LLC, Olympia Fields
University of Chicago Medical Center, Chicago
Advocate Med Group-Heart & Vascular Of Illinois, Chicago
Advanced CardioVascular Consultants, Rock Island
Illinois Heart & Lung Research Center, SC, Normal
Quantum Research LLC, Festus
Center for Advanced Medicine and Research LLC, Bridgeton
VA St. Louis Health Care System (VASTLHCS), St Louis
SLUCare Cardiology, St Louis
Washington University, St Louis
Clinical Investigators LLC, St Louis
Consult and Research Associates, St Louis
Center for Advanced Medicine and Research, City of Saint Peters
Midwest Cardiology Associates, Independence
VA Medical Center Kansas City, Kansas City
Freeman Health System, Joplin
Lake Regional Cardiovascular Institute, Osage Beach
Clinical Research Center University of Missouri, Columbia
CoxHealth: Wheeler Heart & Vascular Center, Springfield
Mercy Medical Research Institute, Springfield
Stahl - Midwest Heart & Vascular Specialists, Overland Park
Professional Research Network of KS, Wichita
Robert J. Dole VAMC, Wichita
Heart Consultants, Omaha
Barrett Clinic, P.C., La Vista
Alegent Creighton Health, Omaha
University of Nebraska Medical Center, Omaha
American Clinical Research, LLC, Marrero
Tulane University Office of Health Research, New Orleans
North Oaks Cardiology, Hammond
Dorothy H. Banish, MD, APMC Study Group, Covington
Avant Research Associates, LLC, Crowley
Veterans Affairs Medical Center Shreveport, Shreveport
Otis Barnum D.O.P.C., Natchitoches
Arkansas Cardiology, Little Rock
Arkansas Heart Hospital, Little Rock
Unity Clinical Research, Lindsay
COR Clinical Research, LLC, Oklahoma City
Thadani - VA Medical Center Oklahoma City, OK, Oklahoma City
Today Clinical Research, Oklahoma City
Cardiovascular Health Clinic, Oklahoma City
Oklahoma State University Center for Health Sciences, Tulsa
IMD Medical Center, Carrollton
Texas Health Physicians Group, Carrollton
Global Medical Research, DeSoto
Cardiovascular Research Institute of Dallas, Dallas
North Texas Health Center, Dallas
The Heart Center of Dallas, Dallas
Grace Research, LLC, Marshall
Grace Research, LLC, Palestine
Heart Center, Palo Pinto General Hospital, Mineral Wells
The Medical Group of Texas, Fort Worth
Texas Health Physicians Group, Fort Worth
T&R Clinic, P.A., Haltom City
North Hills Medical Research, Inc, North Richland Hills
Team Research Of Central Texas, Killeen
Hillcrest Family Health Center, Waco
Michele P. Sartori, MD, Houston
Houston Heart and Vascular Associates, Kingwood
Lone Star Heart and Vascular Center, Tomball
Northwest Houston Clinical Research, Tomball
Acacia Medical Research Institute, Sugar Land
Health Plus Clinical Research, Sugar Land
Grand Medical Care, Katy
Avant Research Associates, LLC, Port Arthur
Southeast TX Clinical Research Center, Beaumont
Santoscoy - Health Texas Research Institute, San Antonio
Element Research Group, San Antonio
Schnitzler Cardiovascular Consultants, San Antonio
San Antonio Endovascular & Heart Institute, San Antonio
Valley Heart Consultants, McAllen
Valley Central Research Inc, Mission
Avant Research Associates LLC, Austin
Texas Heart and Vascular Research, LLC, Austin
Cornerstone Family Medicine, Big Spring
Unrein - Rocky Vista University Health Center, Parker
Vijay - Aurora Denver Cardiology, Denver
Colorado Health Medical Group Heart Center of the Rockies, Fort Collins
Medical Center of the Rockies Research, Fort Collins
Munni R. Selagamsetty, Md, Pc, Colorado Springs
Clinical Research Prime, Idaho Falls
St. Luke's Idaho Cardiology Associates, Boise
Utah Cardiology, P.C., Layton
Utah Diabetes Center, Salt Lake City
Arizona Arthritis & Rheumatology Research, Phoenix
CardioVascular Associates of Mesa, Mesa
Scottsdale Medical Imaging, Scottsdale
The Heart Clinic, Scottsdale
Pima Heart, Tucson
Southern Arizona VA Health Care System, Tucson
Heart Vascular of Northern Arizona, Cottonwood
Presbyterian Heart Group, Albuquerque
Internal Medicine Clinic, Las Vegas
Red Rock Clinical Research, LLC, Las Vegas
Sierra Nevada Health Care System, Reno
Renown Inst for Heart & Vasc Health, Reno
Faye Montegrande Md. Clinical Research, Los Angeles
Eastside Clinical Research Associates, Los Angeles
Salman Khan A. Medical Corporation, Los Angeles
University of Southern California, Los Angeles
West LA VA Medical Center, Los Angeles
Medical Group of Culver City, Culver City
Los Alamitos Cardiovascular, Los Alamitos
Long Beach Center for Clinical Research, Long Beach
Cardiovascular Innovation and Research, Long Beach
Huntington Memorial Hospital, Pasadena
Valley Clinical Trials, Inc., Northridge
Manoj D. Aswani M.D., Thousand Oaks
UCSD Sulpizio Cardiovascular Center, La Jolla
University Of California San Diego, La Jolla
Richard G. Friedman, MD, San Diego
Ritchken and First MDs, San Diego
Foundation for Cardiovascular Medicine, San Diego
San Diego Cardiac Center, San Diego
Veterans Affairs San Diego Healthcare System, San Diego
Desert Medical Care & Wellness, La Quinta
Loma Linda University Health, Loma Linda
VA Loma Linda Healthcare System, Loma Linda
Coastal Heart Medical Group, Inc., Santa Ana
Oracle Clinical Research, Inc., Anaheim
Orange County Heart Institute & Research, Orange
University of CA Irvine Medical Center, Orange
Diverse Research Solutions, Oxnard
Comprehensive Cardiovascular Care, Santa Maria
Kumar Medical Corporation, Lancaster
University Of California San Francisco, Fresno
VACCHCS, Fresno
Central Coast Cardiology, Salinas
UCSF at Zuckerberg SF General Hospital, San Francisco
Touro University California- Solano County Affiliated Clinics, Fairfield
Touro University California- Solano Public Health Affiliated Clinics, Vallejo
Pacific Heart and Vascular Medical Group, Stockton
VA Northern California Health Care, Mather
VA Pacific Islands Health Care System, Honolulu
Oregon Health & Science University, Portland
Samaritan Health Services, Corvallis
Southern Oregon Cardiology, LLC, Medford
Frandsen Family Medicine DBA Sound Medi, Port Orchard
Northwest Medical Associates, P.S., Vancouver
Premier Clinical Research, Spokane
Kootenai Heart Clinics, LLC, Spokane
Northside Internal Medicine, Spokane
Connecticut Heart and Vascular Center, Bridgeport
Bridgeport Hospital, Bridgeport
Maine Research Associates, Auburn
Paul A. Shapero, M.D., Bangor
Southern Maine Health Care, Biddeford
InterMed, PA, Portland
Maine Medical Partners Maine Health Cardiology, South Portland
Maine Centers for Healthcare, Westbrook
Brigham and Women's Hospital, Boston
St. Elizabeth's Medical Center, Boston
MGH Cardiology, Boston
Joslin Diabetes Center, Boston
Lahey Hospital and Medical Center, Burlington
Massachusetts General Hospital - Chelsea Health Care Center, Chelsea
Pentucket Medical Associates, Inc., Haverhill
VA Central Western Massachusetts Healthca, Leeds
South Shore Internal Medicine, Milton
Lahey Medical Center, Peabody
North Shore Cardiovascular Associates, Salem
Reliant Medical Group, Worcester
Lahey Cardiology, Nashua
Family Health at Mount Olive, Flanders
Cardiocare, Hillsborough
New Jersey Heart, Linden
Jersey Shore University Medical Center, Neptune City
Cardiovascular Institute, New Brunswick
Palisade Medical Center, North Bergen
The Valley Hospital, Ridgewood
Mercer Bucks Cardiology, Robbinsville
Cardio Metabolic Institute, Somerset
Holy Name Medical Center, Inc., Teaneck
Total Cardiology Care, LLC, Wayne
Westwood Cardiology Associates, Westwood
Partners in Clinical Research, Cumberland
Ocean State Clinical Research Prtnr, Lincoln
Memorial Hospital of Rhode Island, Pawtucket
The Miriam Hospital, Providence
Ocean State Research Institute, Inc, Providence
VA Medical Center, White River Junction, White River Junction
The Medical Arts Health Research Group, North Vancouver
The Medical Arts Health Research Group, Penticton
Winnipeg Clinic, Winnipeg
Bramalea Medical Centre, Brampton
Brampton Research Associates, Brampton
Philippe R Beaudry Medicine Professional Corporation, Burlington
Vizel Cardiac Research, Cambridge
Dr. Linda Sinnaeve's Office, Chatham
Scisco Clinical Research, Cornwall
G.S. Cardiac Lab Medicine Professional Corp, Greater Sudbury
Dr. R. Labonte Professional Med Corp, Greater Sudbury
Dr. G. Garrioch, Independent Practice, Greater Sudbury
Dr. Peter Spadafora Health Center, Guelph
John Stimac, MD, Hamilton
KMH Cardiology & Diagnostics: Hamilton, Hamilton
Dr. William Liang, Hamilton
Source Unique Clinic, Hawkesbury
Dr. Ronald Fowlis, Kitchener
University Hospital, London
Malton Medical Research, Mississauga
KMH Cardiology & Diagnostics: Mississauga, Mississauga
Sewa Ram Singal Medicine Professional Corporation, Mississauga
Newmarket Cardiology Research Group, Newmarket
Newmarket Cardiology Research Group, Newmarket
Portage Medical Centre, Niagara Falls
Humber River Regional Hospital, North York
Bakbak Medicine Professional Corporation, Oshawa
Dr. James Y. Cha, Oshawa
University Of Ottawa Heart Institute, Ottawa
Kawartha Cardiology Clinical Trials, Peterborough
Steeple Hill Medical Centre, Pickering
Sarnia Institute Of Clinical Research, Sarnia
Scarborough Cardiology Research, Scarborough Village
Scarborough General Hospital Cardiology Research Associates, Scarborough Village
Milliken Medical Centre, Scarborough Village
Canadian Centre for Research on Diabetes, Smith Falls
Lake Shore Cardiology, St. Catharines
Sardar Medical Clinic, St. Thomas
Dr. Laurence Gibbs Medicine Professional Corp., Thedford
Tillsonburg Medical Centre, Tillsonburg
Humber River Hospital, Toronto
Sunnybrook Health Sciences Centre, Toronto
St. Michael's Hospital, Toronto
Mount Sinai Hospital, Toronto
Toronto General Hospital, Toronto
Weston Road Medical Clinic, Toronto
Dr. Nigel Jagan Medicine Professional Corporation, Whitby
Dr. Nwadiaro Medicine Professional Corp, Windsor
Viacar Recherche Clinique Inc., Brossard
Ecogene-21, Chicoutimi
Q&T Research Chicoutimi, Chicoutimi
Viacar Recherche Clinique Inc., Greenfield Park
CHUM Hotel-Dieu, Montreal
Recherche Clinique Sigma, Inc., Québec
Iucpq, Québec
ALPHA Recherche Clinique, Québec
CardioVasc HR, Saint-Jean-sur-Richelieu
ViaCar Recherche Clinique Inc, Saint-Lambert
Viacar Recherche Clinique, Saint-Lambert
Hopital Pierre-Le Gardeur, Terrebonne
Instituto Sanacoop, Bayamón
San Juan Bautista School of Medicine, Caguas
Norma S. Severino-Pacheco, MD, Canovanas
Cardiometabolic Research Center, Ponce
Miguel Sosa-Padilla, MD, San Juan
Yolanda Sierra Quinones, MD, Toa Baja
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Brigham and Women's Hospital
OTHER