Decitabine and Vorinostat Conditioning Followed by CD3-/CD19- NK Cells Infusion for High Risk Myelodysplastic Syndromes

PHASE2CompletedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

March 31, 2013

Primary Completion Date

October 23, 2018

Study Completion Date

October 23, 2018

Conditions
Myelodysplastic Syndrome
Interventions
DRUG

Decitabine

administered intravenous (IV), 10 mg/m\^2/day over 1 hour on days 1-5.

DRUG

Vorinostat

200 mg by mouth (PO) twice a day on days 6-15

BIOLOGICAL

Interleukin-2

6 million Units subcutaneous (SQ) 3 times a week for 3 doses beginning day 17

OTHER

Natural killer (NK) cells

infusion intravenously (IV) over 15 to 60 minutes day 17

Trial Locations (2)

55455

Masonic Cancer Center, University of Minnesota, Minneapolis

55901

Mayo Clinic, Rochester

Sponsors

Collaborators (1)

All Listed Sponsors
lead

Masonic Cancer Center, University of Minnesota

OTHER

collaborator

Mayo Clinic

OTHER

NCT01593670 - Decitabine and Vorinostat Conditioning Followed by CD3-/CD19- NK Cells Infusion for High Risk Myelodysplastic Syndromes | Biotech Hunter | Biotech Hunter