PROMUS Element Plus US Post-Approval Study

PHASE4CompletedINTERVENTIONAL
Enrollment

2,681

Participants

Timeline

Start Date

May 31, 2012

Primary Completion Date

August 31, 2014

Study Completion Date

June 30, 2018

Conditions
Coronary Artery Disease
Interventions
DEVICE

PROMUS Element Plus Coronary Stent System

PROMUS Element is a device/drug combination product composed of two components, a device (coronary stent) and a drug product (a formulation of everolimus contained in a polymer coating).

DRUG

Aspirin

Aspirin should be taken daily (81 mg) for 3 days prior to the procedure or as a peri-procedural loading dose of 250-500 mg. A maintenance dose of aspirin of at least 81 mg daily, or as indicated by the treating physician, should be continued indefinitely.

DRUG

P2Y12 antagonist

"Patients to take one of the following P2Y12 antagonists; maintenance doses to be continued per ACC/AHA/SCAI guidelines for PCI.~* Clopidogrel: Per treating physician, peri-procedural loading dose (300-600 mg), subsequent maintenance dose (75 mg daily)~* Prasugrel: Per treating physician, peri-procedural loading dose (60 mg), subsequent maintenance dose (10 or 5 mg daily per product labeling)~* Ticagrelor: Per treating physician, peri-procedural loading dose (180 mg), subsequent maintenance dose (90 mg 2x daily); maintenance aspirin doses \>100 mg may reduce ticagrelor effectiveness and should be avoided.~* Ticlopidine: Per treating physician, if allergy/intolerance to clopidogrel, prasugrel, and/or ticagrelor, loading dose (500 mg), subsequent maintenance dose (250 mg 2x daily)"

Trial Locations (52)

10011

New York University Medical Center, New York

13501

St. Elizabeth Medical Center, Utica

18901

Doylestown Hospital, Doylestown

19104

Presbyterian University of Pennsylvania Medical Center, Philadelphia

19718

Christiana Hospital, Newark

23225

Chippenham Medical Center, Richmond

24014

Carilion Roanoke Memorial Hospital, Roanoke

28204

Novant Health Presbyterian Medical Center, Charlotte

29572

Grand Strand Regional Medical Center, Myrtle Beach

29605

University Medical Center-Greenville Memorial Hospital, Greenville

29607

St. Francis Health System - St. Francis Hospital, Greenville

30165

Redmond Regional Medical Center, Rome

30309

Piedmont Hospital, Atlanta

31217

Coliseum Medical Center, Macon

32401

Bay Medical Center, Panama City

32605

North Florida Regional Medical Center, Gainesville

32806

Orlando Regional Medical Center, Orlando

33021

Memorial Regional Hospital, Hollywood

33140

Mount Sinai Medical Center, Miami Beach

33511

Brandon Regional Hospital, Brandon

34996

Martin Memorial Health Systems - Martin Memorial Medical Center, Stuart

35801

Huntsville Hospital - The Heart Center, PC, Huntsville

36608

Springhill Medical Center, Mobile

39401

Forest County General Hospital, Hattiesburg

40504

St. Joseph Hospital, Lexington

46032

IU Health North Medical Center, Carmel

46237

Franciscan St. Francis Hospital, Indianapolis

46250

Community Heart and Vascular Hospital, Indianapolis

49085

Lakeland Hospitals at St. Joseph, Saint Joseph

53713

Meriter Hospital, Madison

55102

United Hospital - St. Paul Heart Clinic, Saint Paul

55422

North Memorial Medical Center, Minneapolis

55433

Mercy Hospital, Coon Rapids

55476

Marshfiled Clinic, Weston

57108

Avera Heart Hospital of South Dakota, Sioux Falls

57701

Rapid City Regional Hospital, Rapid City

62301

Blessing Hospital, Quincy

65804

St. John's Regional Health Center (Springfield), Springfield

65807

Cox Medical Centers, Springfield

71103

Cardiovascular Research, LLC, Shreveport

72401

NEA Baptist Memorial Hospital, Jonesboro

St. Bernard's Medical Center, Jonesboro

74136

St. Francis Hospital, Tulsa

75216

VA North Texas Health Care System, Dallas

75231

Presbyterian Hospital of Dallas, Dallas

78745

South Austin Hospital, Austin

84132

University of Utah Hospital and Clinics, Salt Lake City

92354

Loma Linda University Medical Center, Loma Linda

95819

Mercy General Hospital, Sacramento

04401

Eastern Maine Medical Center, Bangor

02601

Cape Cod Hospital, Hyannis

07601

Hackensack University Medical Center, Hackensack

Sponsors
All Listed Sponsors
lead

Boston Scientific Corporation

INDUSTRY