112
Participants
Start Date
June 30, 2011
Primary Completion Date
December 31, 2016
Study Completion Date
December 31, 2016
Lithium
Therapeutic dosage as indicated by participants condition with blood levels. LI will be dosed to attain Li of ≥0.5mEq/L (milliequivalents per liter).
Divalproex
DV will be dosed to attain DV levels of ≥45mg/L.
Lamotrigine
LM will be incrementally dosed up to 400 mg/day, or, in combination with DV, 200 mg/day. Dosage may be reduced for adverse effects to one half of the target dose.
Quetiapine
QT will be started at 50 mg/day and titrated up to 300 mg as tolerated. QT will be discontinued if not tolerated at 100mg/day and the patient will be treated according to guidelines.
Case Western Reserve University, Cleveland
University of Texas Health Science Center, San Antonio
National Institute of Mental Health (NIMH)
NIH
The University of Texas Health Science Center at San Antonio
OTHER