Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction

PHASE2CompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

April 30, 2012

Primary Completion Date

November 30, 2013

Study Completion Date

January 31, 2016

Conditions
Myocardial InfarctionReperfusion InjuryMyocardial IschemiaCardiovascular Diseases
Interventions
DRUG

Sodium Nitrite

A bolus of sodium nitrite solution (1.8 micromol in 10 ml PRe-diluted in 0.9% sodium chloride in a syringe) will be delivered over 30-60 seconds via intracoronary injection initiated during the re-establishment of antegrade epicardial flow with PPCI.

DRUG

Sodium Chloride Placebo

The control intervention is a bolus of 0.9% sodium chloride solution (prepared with an identical appearance to the sodium nitrite).

Trial Locations (1)

E2 9JX

London Chest Hospital, Bethnal Green

All Listed Sponsors
collaborator

Queen Mary University of London

OTHER

lead

Barts & The London NHS Trust

OTHER

NCT01584453 - Safety and Effectiveness of Intra-coronary Nitrite in Acute Myocardial Infarction | Biotech Hunter | Biotech Hunter