Study of OBINUTUZUMAB Combined to LENALIDOMIDE for the Treatment of Relapsed/Refractory Follicular and Aggressive B-cell Lymphoma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

317

Participants

Timeline

Start Date

October 3, 2012

Primary Completion Date

July 11, 2018

Study Completion Date

May 20, 2022

Conditions
Follicular Lymphoma Patients (Phase IB)Follicular and Agressive (DLBCL&MCL) B-cell Lymphoma Patients (Phase II)
Interventions
DRUG

Lenalidomide and GA101

1000mg of GA101 on D8, D15 and D22of cycle 1 and on D1 of cycles 2 to 6. Oral lenalidomide once daily at 10/15/20/25mg (phase I part) or at recommended dose (phase II part) on days 1 to 21 of a 28-day cycle for the first cycle and on days 2 to 22 of a 28-day cycle for cycles 2 to 6.

Trial Locations (25)

1000

institut Jules Bordet, Brussels

1200

Université Catholique de Louvain Saint Luc, Brussels

2060

ZNA Stuivenberg, Antwerp

4000

CHU de Liège, Liège

5530

Université Catholique de Louvain Mont Godinne, Yvoir

8000

A.Z. Sint Jan AV, Bruges

8500

AZ Groeninge - Campus Maria's Voorzienigheid, Kortrijk

13273

Institut Paoli Calmette, Marseille

14076

Institut d'Hématologie de Basse Normandie, Caen

21034

CHU de Dijon, Dijon

33076

Institut Bergonié, Bordeaux

33604

Centre François Magendie, Pessac

34295

CHU St Eloi, Montpellier

35003

CHU Pontchaillou, Rennes

38043

CHU de Grenoble, Grenoble

44093

CHU Hôtel Dieu, Nantes

54511

CHU Brabois, Nancy

59037

CHRU de Lille, Lille

63000

CHU d'Estaing, Clermont-Ferrand

69373

Centre Léon Bérard, Lyon

69495

CH Lyon Sud, Pierre-Bénite

75475

Hôpital St Louis, Paris

76038

Centre henri Becquerel, Rouen

80054

CHU d'Amiens, Amiens

94010

Hôpital Henri Mondor, Créteil

All Listed Sponsors
lead

The Lymphoma Academic Research Organisation

OTHER

NCT01582776 - Study of OBINUTUZUMAB Combined to LENALIDOMIDE for the Treatment of Relapsed/Refractory Follicular and Aggressive B-cell Lymphoma | Biotech Hunter | Biotech Hunter