Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial

PHASE3CompletedINTERVENTIONAL
Enrollment

443

Participants

Timeline

Start Date

January 31, 2009

Primary Completion Date

April 30, 2017

Study Completion Date

June 30, 2017

Conditions
Type 1 Diabetes
Interventions
DRUG

Statin

10mg daily for a minimum period of 2 years

DRUG

ACE inhibitor

Starting dose of 5mg daily rising after 14 days to 10mg daily providing it is well tolerated for a minimum period of 2 years.

DRUG

Placebo

Participants receive statin placebo and ACEI placebo

DRUG

Combination therapy

Participants receive both active statin and active ACEI. Dose for Statins is 10mg daily. Dosing for ACEI starts at 5mg daily rising to 10mg after 14 days providing it is well tolerated. Both interventions last for a minimum of 2 years.

Trial Locations (2)

Unknown

University of Western Australia, Perth

Hospital for Sick Children, Toronto

All Listed Sponsors
collaborator

Juvenile Diabetes Research Foundation

OTHER

collaborator

Diabetes UK

OTHER

collaborator

British Heart Foundation

OTHER

collaborator

Pfizer

INDUSTRY

collaborator

The University of Western Australia

OTHER

collaborator

The Hospital for Sick Children

OTHER

collaborator

University of Oxford

OTHER

collaborator

St Thomas' Hospital, London

OTHER

lead

University of Cambridge

OTHER