Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases

PHASE2CompletedINTERVENTIONAL
Enrollment

69

Participants

Timeline

Start Date

January 31, 2012

Primary Completion Date

January 31, 2015

Study Completion Date

January 31, 2015

Conditions
Lung AdenocarcinomaBrain Metastases
Interventions
DRUG

erlotinib

150 mg given orally (po), daily (QD), starting on the 4th day of each cycle, ending on the 21th day before the next cycle, and until disease PD

DRUG

pemetrexed

500 mg/m² intravenous (iv) over 15 minutes on the first day of each 21-day cycle until disease progression (PD) or unacceptable toxicity or no more than 6 cycles

DRUG

cisplatin

cisplatin 20mg/m² iv on the 1st-3rd day (if PS\<2) or 30 mg iv on the 1st-2nd day (if PS=2 or 3)of each cycle until PD or unacceptable toxicity or no more than 6 cycles

DRUG

erlotinib

150 mg given orally (po), daily (QD), starting on the first day of the first cycle

Trial Locations (1)

510120

The first affiliated hospital of Guangzhou MC, Guangzhou

All Listed Sponsors
lead

Guangzhou Medical University

OTHER

NCT01578668 - Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases | Biotech Hunter | Biotech Hunter