A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler (Puffer) in Adolescents and Adults Who Have Asthma That is Not Controlled by High Dose Inhaled Corticosteroid Asthma Medications

PHASE2CompletedINTERVENTIONAL
Enrollment

889

Participants

Timeline

Start Date

April 30, 2012

Primary Completion Date

July 31, 2013

Study Completion Date

October 31, 2013

Conditions
Asthma
Interventions
DRUG

Fp MDPI

"Fp MDPI is an inhalation-driven multidose dry powder inhaler (MDPI) containing fluticasone propionate (Fp) dispersed in a lactose monohydrate excipient and contained within a reservoir. A metered dose of drug is delivered to a dose cup via an air pulse activated when the cap is opened.~During the treatment period, participants were randomized to 50, 100, 200 or 400 mcg of Fp one inhalation twice a day for a total daily dose of 100, 200, 400 or 800 mcg. Study drug was administered in the morning and in the evening."

OTHER

Placebo MDPI

Placebo multidose dry powder inhaler (MDPI) in the morning and evening. Placebo MDPI was provided in devices identical in appearance to Fp MDPI.

DRUG

Flovent Diskus

Flovent Diskus contains the active ingredient fluticasone propionate (Fp). Flovent Diskus 250 mcg was used twice a day, once in the morning and evening, for a total daily dose of 500 mcg of Fp. This therapy was not blinded as the inhaler device was different than the MDPI used in the other treatment arms.

DRUG

albuterol/salbutamol

A short-acting β2-adrenergic agonists (SABA), albuterol/salbutamol hydrofluoroalkane (HFA) metered dose inhaler (MDI), was provided to be used as needed for the relief of asthma symptoms during both the run-in and treatment periods (to replace the subject's current rescue medication).

Trial Locations (300)

Unknown

Teva Investigational Site 10504, Birmingham

Teva Investigational Site 10565, Homewood

Teva Investigational Site 11527, Goodyear

Teva Investigational Site 10516, Tucson

Teva Investigational Site 10573, Bakersfield

Teva Investigational Site 11518, Costa Mesa

Teva Investigational Site 10590, Fountain Valley

Teva Investigational Site 10551, Granada Hills

Teva Investigational Site 11520, Huntington Beach

Teva Investigational Site 11545, Huntington Beach

Teva Investigational Site 10547, Long Beach

Teva Investigational Site 11549, Los Angeles

Teva Investigational Site 10503, Mission Viejo

Teva Investigational Site 10536, Newport Beach

Teva Investigational Site 10540, Orange

Teva Investigational Site 11551, Orange

Teva Investigational Site 10578, Palmdale

Teva Investigational Site 10585, Redwood City

Teva Investigational Site 11538, Rolling Hills Estates

Teva Investigational Site 11522, Roseville

Teva Investigational Site 10582, San Diego

Teva Investigational Site 11554, San Diego

Teva Investigational Site 10563, San Jose

Teva Investigational Site 11556, Santa Monica

Teva Investigational Site 10506, Stockton

Teva Investigational Site 10529, Walnut Creek

Teva Investigational Site 10545, Centennial

Teva Investigational Site 10572, Colorado Springs

Teva Investigational Site 10533, Denver

Teva Investigational Site 11531, Denver

Teva Investigational Site 11542, Denver

Teva Investigational Site 11569, Wheat Ridge

Teva Investigational Site 10528, Waterbury

Teva Investigational Site 10556, Boynton Beach

Teva Investigational Site 11513, Brandon

Teva Investigational Site 11507, Clearwater

Teva Investigational Site 11546, Fort Myers

Teva Investigational Site 11526, Hialeah

Teva Investigational Site 11525, Kissimmee

Teva Investigational Site 10537, Miami

Teva Investigational Site 10553, Miami

Teva Investigational Site 11508, Miami

Teva Investigational Site 11514, Miami

Teva Investigational Site 11516, Miami

Teva Investigational Site 11530, Miami

Teva Investigational Site 11570, Miami

Teva Investigational Site 10571, Ocala

Teva Investigational Site 11537, Sarasota

Teva Investigational Site 10593, South Miami

Teva Investigational Site 11555, Tallahassee

Teva Investigational Site 10554, Tamarac

Teva Investigational Site 10539, Tampa

Teva Investigational Site 10525, Valrico

Teva Investigational Site 11504, Albany

Teva Investigational Site 10511, Columbus

Teva Investigational Site 11510, Columbus

Teva Investigational Site 11572, Columbus

Teva Investigational Site 10568, Lawrenceville

Teva Investigational Site 10586, Lilburn

Teva Investigational Site 11539, Savannah

Teva Investigational Site 10543, Stockbridge

Teva Investigational Site 11558, Indianapolis

Teva Investigational Site 10527, South Bend

Teva Investigational Site 10584, Iowa City

Teva Investigational Site 11501, Overland Park

Teva Investigational Site 10591, Lexington

Teva Investigational Site 11567, Louisville

Teva Investigational Site 10513, Metairie

Teva Investigational Site 10564, Bangor

Teva Investigational Site 11548, Baltimore

Teva Investigational Site 10510, Largo

Teva Investigational Site 10577, Wheaton

Teva Investigational Site 10538, Brockton

Teva Investigational Site 10546, North Dartmouth

Teva Investigational Site 11502, Troy

Teva Investigational Site 10531, Plymouth

Teva Investigational Site 11562, Columbia

Teva Investigational Site 11563, Columbia

Teva Investigational Site 10552, St Louis

Teva Investigational Site 10575, St Louis

Teva Investigational Site 10589, St Louis

Teva Investigational Site 11532, St Louis

Teva Investigational Site 10518, Bellevue

Teva Investigational Site 10550, Omaha

Teva Investigational Site 11529, Omaha

Teva Investigational Site 11571, Las Vegas

Teva Investigational Site 10559, Cherry Hill

Teva Investigational Site 11566, Edison

Teva Investigational Site 10501, Hillsborough

Teva Investigational Site 11550, Ocean City

Teva Investigational Site 10588, West Orange

Teva Investigational Site 11503, Albuquerque

Teva Investigational Site 10587, Brooklyn

Teva Investigational Site 10520, New York

Teva Investigational Site 10532, Newburgh

Teva Investigational Site 10567, North Syracuse

Teva Investigational Site 10512, Rochester

Teva Investigational Site 10580, The Bronx

Teva Investigational Site 10522, Canton

Teva Investigational Site 10507, Cincinnati

Teva Investigational Site 10523, Cincinnati

Teva Investigational Site 10544, Columbus

Teva Investigational Site 11521, Dayton

Teva Investigational Site 11505, Middleburg Heights

Teva Investigational Site 10560, Oklahoma City

Teva Investigational Site 10574, Oklahoma City

Teva Investigational Site 10579, Oklahoma City

Teva Investigational Site 11544, Tulsa

Teva Investigational Site 10598, Ashland

Teva Investigational Site 11543, Medford

Teva Investigational Site 11557, Portland

Teva Investigational Site 10509, Altoona

Teva Investigational Site 10555, Philadelphia

Teva Investigational Site 10566, Pittsburgh

Teva Investigational Site 10521, Upland

Teva Investigational Site 10581, Lincoln

Teva Investigational Site 10562, Providence

Teva Investigational Site 10526, Charleston

Teva Investigational Site 11547, Charleston

Teva Investigational Site 10583, Orangeburg

Teva Investigational Site 10517, Spartanburg

Teva Investigational Site 11515, Spartanburg

Teva Investigational Site 10519, Boerne

Teva Investigational Site 10541, Dallas

Teva Investigational Site 10542, Dallas

Teva Investigational Site 10548, El Paso

Teva Investigational Site 11552, El Paso

Teva Investigational Site 11512, Fort Worth

Teva Investigational Site 11565, Houston

Teva Investigational Site 11568, Houston

Teva Investigational Site 10515, San Antonio

Teva Investigational Site 10569, San Antonio

Teva Investigational Site 11517, San Antonio

Teva Investigational Site 11519, San Antonio

Teva Investigational Site 11560, Waco

Teva Investigational Site 11528, Layton

Teva Investigational Site 10576, Provo

Teva Investigational Site 10534, South Burlington

Teva Investigational Site 10502, Fairfax

Teva Investigational Site 10595, Manassas

Teva Investigational Site 10508, Richmond

Teva Investigational Site 11561, Bellingham

Teva Investigational Site 11541, Seattle

Teva Investigational Site 10524, Spokane

Teva Investigational Site 10530, Tacoma

Teva Investigational Site 11511, Tacoma

Teva Investigational Site 10570, Greenfield

Teva Investigational Site 11559, Greenfield

Teva Investigational Site 85570, Bedford Park

Teva Investigational Site 85571, Parkville

Teva Investigational Site 59507, Burgas

Teva Investigational Site 59503, Lovech

Teva Investigational Site 59506, Pleven

Teva Investigational Site 59504, Rousse

Teva Investigational Site 59501, Sofia

Teva Investigational Site 59502, Sofia

Teva Investigational Site 59505, Sofia

Teva Investigational Site 59508, Sofia

Teva Investigational Site 59509, Varna

Teva Investigational Site 11594, Burlington

Teva Investigational Site 11595, Etobicoke

Teva Investigational Site 11592, Sarnia

Teva Investigational Site 11590, Toronto

Teva Investigational Site 11591, Newmarket

Teva Investigational Site 85501, Zagreb

Teva Investigational Site 85502, Zagreb

Teva Investigational Site 85503, Zagreb

Teva Investigational Site 85504, Zagreb

Teva Investigational Site 70561, Berlin

Teva Investigational Site 70564, Bonn

Teva Investigational Site 70557, Cottbus

Teva Investigational Site 70553, Delitzsch

Teva Investigational Site 70558, Frankfurt

Teva Investigational Site 70562, Hamburg

Teva Investigational Site 70560, Hanover

Teva Investigational Site 70555, Leipzig

Teva Investigational Site 70556, Magdeburg

Teva Investigational Site 70550, München

Teva Investigational Site 70554, München

Teva Investigational Site 70552, Münster

Teva Investigational Site 70563, Nuremberg

Teva Investigational Site 70551, Rudersdorf

Teva Investigational Site 70559, Wiesbaden

Teva Investigational Site 85533, Athens

Teva Investigational Site 85534, Athens

Teva Investigational Site 85531, Heraklion

Teva Investigational Site 85532, Larissa

Teva Investigational Site 85530, Thessaloniki

Teva Investigational Site 36507, Balassagyarmat

Teva Investigational Site 36504, Budapest

Teva Investigational Site 36505, Budapest

Teva Investigational Site 36514, Csoma

Teva Investigational Site 36516, Érd

Teva Investigational Site 36513, Kaba

Teva Investigational Site 36515, Kaposvár

Teva Investigational Site 36503, Miskolc

Teva Investigational Site 36502, Nyíregyháza

Teva Investigational Site 36510, Siófok

Teva Investigational Site 36517, Szarvas

Teva Investigational Site 36508, Százhalombatta

Teva Investigational Site 36506, Szeged

Teva Investigational Site 36509, Szeged

Teva Investigational Site 36501, Szombathely

Teva Investigational Site 36512, Veszprém

Teva Investigational Site 59550, Dublin

Teva Investigational Site 59551, Dublin

Teva Investigational Site 72511, Ashkelon

Teva Investigational Site 72501, Haifa

Teva Investigational Site 72512, Haifa

Teva Investigational Site 72502, Jerusalem

Teva Investigational Site 72504, Jerusalem

Teva Investigational Site 72509, Kfar Saba

Teva Investigational Site 72506, Petah Tikva

Teva Investigational Site 72507, Ramat Gan

Teva Investigational Site 72503, Rehovot

Teva Investigational Site 72508, Tel Aviv

Teva Investigational Site 72510, Tel Aviv

Teva Investigational Site 72505, Ẕerifin

Teva Investigational Site 81571, Auckland

Teva Investigational Site 81572, Christchurch

Teva Investigational Site 81573, Tauranga

Teva Investigational Site 81570, Wellington

Teva Investigational Site 48507, Bialystok

Teva Investigational Site 48505, Bydgoszcz

Teva Investigational Site 48506, Grodzisk Mazowiecki

Teva Investigational Site 48501, Lodz

Teva Investigational Site 48509, Lodz

Teva Investigational Site 48513, Lublin

Teva Investigational Site 48508, Poznan

Teva Investigational Site 48512, Poznan

Teva Investigational Site 48502, Strzelce Opolskie

Teva Investigational Site 48503, Tarnów

Teva Investigational Site 48504, Wroclaw

Teva Investigational Site 81534, Brasov

Teva Investigational Site 81539, Brasov

Teva Investigational Site 81533, Bucharest

Teva Investigational Site 81535, Bucharest

Teva Investigational Site 81537, Bucharest

Teva Investigational Site 81531, Cluj-Napoca

Teva Investigational Site 81536, Cluj-Napoca

Teva Investigational Site 81530, Târgu Mureş

Teva Investigational Site 81532, Timișoara

Teva Investigational Site 81538, Timișoara

Teva Investigational Site 70505, Barnaul

Teva Investigational Site 70502, Kazan'

Teva Investigational Site 70511, Moscow

Teva Investigational Site 70512, Moscow

Teva Investigational Site 70508, Ryazan

Teva Investigational Site 70501, Saint Petersburg

Teva Investigational Site 70504, Saint Petersburg

Teva Investigational Site 70510, Saint Petersburg

Teva Investigational Site 70509, Samara

Teva Investigational Site 70507, Smolensk

Teva Investigational Site 70506, Tomsk

Teva Investigational Site 70503, Yaroslavl

Teva Investigational Site 81501, Belgrade

Teva Investigational Site 36551, Bloemfontein

Teva Investigational Site 36552, Cape Town

Teva Investigational Site 36555, Cape Town

Teva Investigational Site 36550, Port Elizabeth

Teva Investigational Site 36553, Thabazimbi

Teva Investigational Site 36554, Witbank

Teva Investigational Site 34507, Aranjuez

Teva Investigational Site 34501, Badalona

Teva Investigational Site 34502, Barcelona

Teva Investigational Site 34510, Barcelona

Teva Investigational Site 34509, Bilbao

Teva Investigational Site 34506, Lleida

Teva Investigational Site 34505, Madrid

Teva Investigational Site 34503, Salt

Teva Investigational Site 34504, Santiago de Compostela

Teva Investigational Site 34508, Valencia

Teva Investigational Site 34511, Vitoria-Gasteiz

Teva Investigational Site 80501, Dnipropetrovsk

Teva Investigational Site 80513, Dnipropetrovsk

Teva Investigational Site 80511, Donetsk

Teva Investigational Site 80502, Kharkiv

Teva Investigational Site 80503, Kharkiv

Teva Investigational Site 80504, Kyiv

Teva Investigational Site 80505, Kyiv

Teva Investigational Site 80506, Kyiv

Teva Investigational Site 80507, Kyiv

Teva Investigational Site 80508, Kyiv

Teva Investigational Site 80509, Kyiv

Teva Investigational Site 80517, Kyiv

Teva Investigational Site 80519, Kyiv

Teva Investigational Site 80520, Kyiv

Teva Investigational Site 80521, Kyiv

Teva Investigational Site 80514, Odesa

Teva Investigational Site 80516, Simferopol

Teva Investigational Site 80512, Vinnytsia

Teva Investigational Site 80515, Yalta

Teva Investigational Site 80522, Zaporizhia

Teva Investigational Site 80510, Zaporizhzhia

Teva Investigational Site 80518, Zaporizhzhya

Teva Investigational Site 34582, Cottingham

Teva Investigational Site 34584, London

Teva Investigational Site 34585, Penzance

Teva Investigational Site 34580, Torpoint

Teva Investigational Site 34581, Watford

All Listed Sponsors
lead

Teva Branded Pharmaceutical Products R&D, Inc.

INDUSTRY

NCT01576718 - A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler (Puffer) in Adolescents and Adults Who Have Asthma That is Not Controlled by High Dose Inhaled Corticosteroid Asthma Medications | Biotech Hunter | Biotech Hunter