Open-Label Extension of Study R727-CL-1003 (NCT01266876) to Evaluate the Long-Term Safety and Efficacy of Alirocumab (REGN727) in Participants With Heterozygous Familial Hypercholesterolemia (HeFH)

PHASE2CompletedINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

February 28, 2012

Primary Completion Date

December 22, 2016

Study Completion Date

December 22, 2016

Conditions
HypercholesterolemiaHeterozygous Familial Hypercholesterolemia
Interventions
DRUG

Alirocumab

Alirocumab was supplied in a pre-filled syringe and administered subcutaneously (SC) in the abdomen, thigh, or outer upper arm; REGN727(SAR236553) is an anti-PCSK9 (proprotein convertase subtilisin/kexin type 9) antibody

DRUG

Placebo Matched to Alirocumab

Placebo matched to alirocumab was supplied in a pre-filled syringe and administered subcutaneously (SC) in the abdomen, thigh, or outer upper arm; REGN727(SAR236553) is an anti-PCSK9 (proprotein convertase subtilisin/kexin type 9) antibody

Trial Locations (14)

Unknown

Mission Viejo

Newport Beach

Thousand Oaks

Miami

Port Orange

Kansas City

Auburn

St Louis

Durham

Cincinnati

Houston

Chicoutimi

Montreal

Sainte-Foy

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Sanofi

INDUSTRY

lead

Regeneron Pharmaceuticals

INDUSTRY