Carfilzomib, Lenalidomide, and Dexamethasone for Smoldering Multiple Myeloma

PHASE2CompletedINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

May 29, 2012

Primary Completion Date

March 3, 2022

Study Completion Date

February 28, 2025

Conditions
Multiple Myeloma
Interventions
DRUG

Carfilzomib

Carfilzomib intravenous (IV) 20-36 mg/m\^2 per dose on days 1, 2, 8, 9, 15, and 16 of each cycle based on arm; until disease progression or unacceptable toxicity.

DRUG

Revlimid

Revlimid by mouth (PO) 25 mg/day, days 1-21 every 28 days of each cycle based on arm; until disease progression or unacceptable toxicity.

DRUG

Dexamethasone

Dexamethasone by mouth (PO) 20 mg per dose on days 1, 2, 8, 9, 15, 16, 22, and 23 of each cycle based on arm; until disease progression or unacceptable toxicity.

Trial Locations (1)

20892

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT01572480 - Carfilzomib, Lenalidomide, and Dexamethasone for Smoldering Multiple Myeloma | Biotech Hunter | Biotech Hunter