19
Participants
Start Date
May 31, 2012
Primary Completion Date
July 31, 2013
Study Completion Date
July 31, 2013
varenicline (Chantix)
For the first 3 days after being switched from NRT (occurring at one week before the rescheduled quit date), smokers in this group will receive varenicline at a dose of 0.5 mg once per day followed by 0.5 mg twice a day for the remaining 4 days of that week. Subsequently, the dose will be 1 mg twice per day, and will remain at that dose for the remainder of the 12 weeks.
bupropion (Zyban)
After being switched from NRT (occurring at one week before the rescheduled quit date), smokers in this group will receive 150mg of bupropion once daily and 21mg nicotine patch for first 3 days; 150mg of bupropion twice daily and 21mg nicotine patch for 7 weeks; 150mg of bupropion twice daily and 14mg nicotine patch for 2 weeks and 150mg of bupropion twice daily and 7mg nicotine patch for 2 weeks.
nicotine patches
21mg nicotine patch for first 11 weeks; 14mg nicotine patch for next 2 weeks; 7mg nicotine patch for final 2 weeks.
Duke Center for Smoking Cessation, Raleigh
Duke Center forSmoking Cessation, Durham
Lead Sponsor
Philip Morris USA, Inc.
INDUSTRY
Duke University
OTHER