Involved Field Irradiation (IFI) Versus Elective Nodal Irradiation (ENI) for Esophageal Cancer

NACompletedINTERVENTIONAL
Enrollment

220

Participants

Timeline

Start Date

March 31, 2012

Primary Completion Date

July 31, 2017

Study Completion Date

July 31, 2017

Conditions
Esophageal Squamous Cell Carcinoma
Interventions
RADIATION

Involved Field Irradiation(IFI)

Involved Field Irradiation(IFI):only irradiate positive lymph node by CT or PET-CT Radiation: IMRT IMRT is administered with chemotherapy from week 1 to week 8PTV-GTV(primary tumor):66-70Gy/33\~35F,once a day, 5 times per week PTV-CTV(Clinical target,primary tumor extended 3cm in Axial):50-56Gy/33\~35f,once a day, 5 times per week PTV-GTVnd(positive node):66-70Gy/33\~35F,once a day, 5 times per week.

DRUG

docetaxel and cisplatin

Drug: docetaxel and cisplatin.Consists of docetaxel 60-80mg/m2 day 1 and cisplatin 25mg/m2 days 1 to 3, repeat every 3 weeks, for 2 cycles.

RADIATION

Elective Nodal Irradiation (ENI)

The CTVn of ENI included the involved lymph node regions and clinically uninvolved lymph nodal stations according to the location of primary tumor. Lymph node station numbers 1/2/4/5/7, 2/4/5/7 and 4/5/7/16/17were included for upper, middle and lower thoracic ESCC in the ENI arm respectively.

Trial Locations (4)

530021

Guangxi Tumor Hospital, Nanning

550000

GuiZhou Cancer Hospital, Guiyang

610000

The Second People's Hospital of Sichuan, Chengdu

652100

Yunnan Tumor Hospital, The Third Affiliated Hospital of KUNMING Medical University, Kunming

All Listed Sponsors
lead

Chengya Chou

OTHER

NCT01551589 - Involved Field Irradiation (IFI) Versus Elective Nodal Irradiation (ENI) for Esophageal Cancer | Biotech Hunter | Biotech Hunter