680
Participants
Start Date
August 31, 2012
Primary Completion Date
December 31, 2013
Study Completion Date
December 31, 2013
1:1:1 Blood Transfusion Ratio
Group 1 will be randomized to receive the 1:1:1 ratio of plasma:platelets:RBC. Blood bank will prepare the initial container containing 6 units plasma, 1 unit platelets (a pool of 6 units on average) and 6 units RBC; the blood bank will send the initial and all subsequent containers until notified of the discontinuation of the PROPPR transfusion protocol.
1:1:2 Blood Transfusion Ratio
Group 2 will be randomized to receive the 1:1:2 ratio of plasma:platelets:RBC. The blood bank will prepare the initial container containing 3 units plasma, 0 units platelets and 6 units RBC, a second container containing 3 units plasma, 1 unit platelets (a pool of 6 units on average) and 6 units RBC, and the blood bank will send this sequence of 2 containers repeatedly, until notified of the discontinuation of the PROPPR transfusion protocol.
University of Maryland School of Medicine, Baltimore
University of Alabama, Birmingham
University of Tennessee Health Science Center, Memphis
University of Cincinnati, Cincinnati
Medical College of Wisconsin, Milwaukee
University of Texas Health Science Center- Memorial Hermann Hospital, Houston
University of Arizona, Tucson
University of Southern California, Los Angeles, Los Angeles
University of California, San Francisco, San Francisco
Oregon Health and Science University, Portland
University of Washington- Harborview Medical Center, Seattle
Sunnybrook Health Science Center, Toronto
Collaborators (1)
United States Department of Defense
FED
National Heart, Lung, and Blood Institute (NHLBI)
NIH
Resuscitation Outcomes Consortium
NETWORK
Defence Research and Development Canada
INDUSTRY
The University of Texas Health Science Center, Houston
OTHER