Dose Escalation Study of Cyclophosphamide in HIV-Infected Subjects on HAART Receiving SB-728-T

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

December 31, 2011

Primary Completion Date

July 7, 2017

Study Completion Date

July 7, 2017

Conditions
HIV
Interventions
GENETIC

SB-728-T

Infusion will be 5 to 30 billion ZFN modified CD4+ T cells 1 day following IV cyclophosphamide 200 mg

GENETIC

SB-728-T

Infusion will be 5 to 30 billion ZFN modified CD4+ T cells up to 3 days following IV cyclophosphamide 0.5 g/m2

GENETIC

SB-728-T

Infusion will be 5 to 30 billion ZFN modified CD4+ T cells up to 3 days following IV cyclophosphamide 1.0 g/m2

GENETIC

SB-728-T

Infusion will be 5 to 30 billion ZFN modified CD4+ T cells up to 3 days following IV cyclophosphamide 2.0 g/m2

GENETIC

SB-728-T

Infusion will be 5 to 30 billion ZFN modified CD4+ T cells up to 3 days following IV cyclophosphamide 1.5 g/m2

Trial Locations (11)

10011

Ricky K Hsu, MD, PC, New York

32803

Orlando Immunology Center, Orlando

63108

Central West Clinical Research, Inc., St Louis

75246

North Texas Infectious Diseases Consultants, Dallas

77098

Gordon Crofoot, MD, PA, Houston

78705

Central Texas Clinical Research, Austin

87505

Southwest CARE Center, Santa Fe

90035

UCLA Care Center, Los Angeles

94115

Quest Clinical Research, San Francisco

06850

Circle CARE Center, LLC, Norwalk

00909

Clinical Research Puerto Rico, San Juan

Sponsors
All Listed Sponsors
lead

Sangamo Therapeutics

INDUSTRY