Sofosbuvir + Ribavirin for 12 Weeks in Subjects With Chronic Genotype 2 or 3 Hepatitis C Infection Who Are Interferon Intolerant, Interferon Ineligible or Unwilling to Take Interferon

PHASE3CompletedINTERVENTIONAL
Enrollment

278

Participants

Timeline

Start Date

March 31, 2012

Primary Completion Date

November 30, 2012

Study Completion Date

February 28, 2013

Conditions
Chronic Hepatitis C
Interventions
DRUG

SOF

Sofosbuvir (SOF) 400 mg tablet administered orally once daily

DRUG

RBV

Ribavirin (RBV) was administered as a tablet orally according to package insert weight-based dosing recommendations (\< 75kg = 1000 mg and ≥ 75 kg = 1200 mg).

DRUG

Placebo to match SOF

Placebo to match SOF was administered orally once daily.

DRUG

Placebo to match RBV

Placebo to match RBV was administered orally twice daily.

Trial Locations (63)

1640

Auckland Clinical Studies Limited, Auckland

2145

Westmead Hospital, Westmead

3065

St. Vincent's Hospital, Melbourne

3168

Monash Medical Centre, Melbourne

4029

Royal Brisbane & Women's Hospital, Herston

8011

Christchurch Hospital, Christchurch

10021

Weill Cornell Medical College, New York

10029

Mount Sinai School of Medicine, New York

13903

Binghamton Gastroenterology Associates, Binghamton

19104

University of Pennsylvania, Philadelphia

20009

Whitman Walker Clinic, Washington D.C.

21093

Johns Hopkins University, Lutherville

22031

Metropolitan Research, Fairfax

22042

Inova Fairfax Hospital Center for Liver Diseases, Falls Church

23502

Digestive and Liver Disease Specialists, Norfolk

23602

Liver Institute of Virginia, Bon Secours St.Mary's, Newport News

27103

Digestive Health Specialists, PA, Winston-Salem

27710

Duke University, Durham

30060

Gastrointestinal Specialists of Georgia, PC, Marietta

30309

Digestive Healthcare of Georgia, Atlanta

32256

Borland-Groover Clinic, Jacksonville

32806

Internal Medicine Specialists, Orlando

33136

University of Miami, Center for Liver Diseases, Miami

33414

South Florida Center of Gastroenterology, P.A., Wellington

34653

Advanced Research Institute, New Port Richey

37211

Nashville Gastrointestinal Specialists, Inc, Nashville

38138

Gastro One, Germantown

42101

Graves-Gilbert Clinic, Bowling Green

46237

Indianapolis Gastroenterology Research Foundation, Indianapolis

48377

Henry Ford Health System, Novi

55407

Minnesota Gastroenterology, P.A., Saint Paul

64131

Kansas City Gastroenterology and Hepatology, Kansas City

70809

Gastroenterology Associates, LLC, Baton Rouge

75219

Southwest Infectious Disease Clinical Research, Inc., Dallas

77004

Therapeutic Concepts, PA, Houston

78215

Alamo Medical Research, San Antonio

80045

University of Colorado, Aurora

80113

South Denver Gastroenterology, Englewood

90027

Kaiser Permanente, Los Angeles

90036

Lightspeed Medical, Los Angeles

90069

Anthony Mills MD, Inc., Los Angeles

92103

UCSD Antiviral Research Center, San Diego

92118

SCTI Research Foundation Liver Center, Coronado

92154

Kaiser Permanente, San Diego

94115

Quest Clinical Research, San Francisco

98101

Virginia Mason Medical Center, Seattle

912123

Medical Associates Research Group, San Diego

35294-2170

University of Alabama Birmingham, Birmingham

32610-0277

University of Florida, Gainesville

32803-1851

Orlando Immunology Center (ACH), Orlando

02114-2696

Massachusetts General Hospital, Boston

02115

Beth Israel Deaconess Medical Center, Boston

01105

The Research Institute, Springfield

08009

Comprehensive Clinical Research, Berlin

08844

ID Care, Hillsborough

02905

University Gastroenterology, Providence

T2N 4Z6

University of Calgary, Calgary

V5Z 1M9

Gordon & Leslie Diamond Health Care Centre, Vancouver

V6Z 2K5

(G.I.R.I.) Gastrointestinal Research Institute, Vancouver

M6H 3M1

Toronto Liver Centre, Toronto

H2X 3J4

CHUM - The Research Centre, Montreal

00927

Fundacion De Investigacion De Diego, San Juan

00909-1711

Clinical Research Puerto Rico Inc, San Juan

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY