Tailored Antiplatelet Therapy Versus Recommended Dose of Prasugrel

PHASE4CompletedINTERVENTIONAL
Enrollment

880

Participants

Timeline

Start Date

March 31, 2012

Primary Completion Date

May 31, 2016

Study Completion Date

May 31, 2016

Conditions
Acute Coronary Syndrome
Interventions
DRUG

Modification of Prasugrel based on a biological assay

Monitoring with VerifyNow P2Y12, 2 weeks after initiation of 5 mg of maintenance dose of prasugrel, reduction of antiplatelet therapy if there is high on-treatment platelet inhibition (HPI) or increase in dosing if there is high on-treatment platelet reactivity (HPR) Device: VerifyNow point of care assay VerifyNow (ACCUMETRICS San Diego USA)

DRUG

prasugrel / clopidogrel

fixed dose of prasugrel 5 mg

DEVICE

Verify Now

Monitoring with VerifyNow P2Y12, 2 weeks after initiation of 5 mg of maintenance dose of prasugrel, reduction of antiplatelet therapy if there is high on-treatment platelet inhibition (HPI) or increase in dosing if there is high on-treatment platelet reactivity (HPR) Device: VerifyNow point of care assay VerifyNow (ACCUMETRICS San Diego USA)

Trial Locations (2)

30029

CHU Caremeau à Nimes - Service de Cardiologie, Nîmes

75013

ACTION study group - Institut de Cardiologie- Hôpital la Pitié Salpêtrière, Paris

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

collaborator

Daiichi Sankyo

INDUSTRY

collaborator

Allies in Cardiovascular Trials Initiatives and Organized

OTHER

collaborator

Accumetrics, Inc.

INDUSTRY

collaborator

Stentys

INDUSTRY

lead

Assistance Publique - Hôpitaux de Paris

OTHER