Linsitinib or Topotecan Hydrochloride in Treating Patients With Relapsed Small Cell Lung Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

February 29, 2012

Primary Completion Date

November 30, 2014

Study Completion Date

November 30, 2014

Conditions
Recurrent Small Cell Lung Carcinoma
Interventions
OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Linsitinib

150 mg given orally (PO) twice a day (BID)

OTHER

Pharmacological Study

Correlative studies

DRUG

Topotecan Hydrochloride

1.5 mg/m\^2 intravenously (IV) or 2.3 mg/m\^2 orally (PO)

Trial Locations (11)

21231

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital, Baltimore

30322

Emory University/Winship Cancer Institute, Atlanta

33612

Moffitt Cancer Center, Tampa

37232

Vanderbilt University/Ingram Cancer Center, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

44106

Case Western Reserve University, Cleveland

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53792

University of Wisconsin Hospital and Clinics, Madison

59107

Billings Clinic Cancer Center, Billings

85259

Mayo Clinic in Arizona, Scottsdale

308433

Johns Hopkins Singapore, Singapore

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH

NCT01533181 - Linsitinib or Topotecan Hydrochloride in Treating Patients With Relapsed Small Cell Lung Cancer | Biotech Hunter | Biotech Hunter