Phase II Trial Designed to Determine Efficacy and Safety of Bendamustine+Dexamethasone+Thalidomide in R/R MM

PHASE2CompletedINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 31, 2012

Primary Completion Date

December 31, 2015

Study Completion Date

April 8, 2017

Conditions
Multiple Myeloma
Interventions
DRUG

Bendamustine

Bifunctional alkylating agent consisting of a purine and amino acid antagonist (a benzimidazole ring) and an alkylating nitrogen mustard moiety.

DRUG

Thalidomide

Thalidomide can directly inhibit the growth and survival of myeloma cells, by oxidative damage to DNA mediated by free radicals. The drug can induce apoptosis even in drug resistant myeloma cells. Thalidomide modulates cell adhesion molecule expression, so it may interfere with the mutually stimulatory interactions between myeloma cells and the bone marrow microenvironment.

DRUG

Dexamethasone

It's a corticosteroid.

Trial Locations (19)

30031

Ospedale Civile di Dolo, Dolo

30170

Ospedale dell'Angelo di Mestre, Mestre

31033

Ospedale di Castelfranco Veneto, Castelfranco Veneto

31100

Ospedale Ca Foncello, Treviso

32032

AULSS 2 Feltre, Feltre

32100

Ospedale S. Martino, Belluno

33100

A.O.U S. Maria della Misericordia, Udine

34142

A.O.U Ospedali Riuniti di Trieste Medicina II, Trieste

A.O.U Ospedali Riuniti di Trieste, Trieste

35012

Presidio Ospedaliero di Camposampiero, Camposampiero

35127

A.O di Padova Ematologia e Immunologia Clinica, Padua

A.O di Padova Ematologia, Padua

36100

AULSS 6 Vicenza, Vicenza

37134

Ospedale Policlinico G.B Rossi (Borgo Roma) Ematologia, Verona

Ospedale Policlinico G.B Rossi (Borgo Roma) Medicina II, Verona

38100

Ospedale di Trento - P.O. S. Chiara, Trento

39100

Division of Hematology and CBMT, Bolzano

45100

AULLS 18 di Rovigo, Rovigo

98125

Azienda Ospedaliera Universitaria G. Martino, Messina

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Mundipharma Pte Ltd.

INDUSTRY

lead

Azienda Ospedaliera di Bolzano

OTHER

NCT01526694 - Phase II Trial Designed to Determine Efficacy and Safety of Bendamustine+Dexamethasone+Thalidomide in R/R MM | Biotech Hunter | Biotech Hunter