A Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Cancers

PHASE2CompletedINTERVENTIONAL
Enrollment

208

Participants

Timeline

Start Date

April 12, 2012

Primary Completion Date

October 28, 2016

Study Completion Date

October 28, 2016

Conditions
Multiple Myeloma, Neoplasms
Interventions
DRUG

cetuximab

Escalating doses administered on Day 1 and then once weekly by intravenous infusion.

DRUG

vemurafenib

Escalating doses given orally twice a day starting on Day 2

DRUG

vemurafenib

960 mg vemurafenib orally twice a day until disease progression, unacceptable toxicity, or withdrawal of consent.

Trial Locations (34)

13273

Institut Paoli-Calmettes; Oncologie Medicale 1, Marseille

14076

Centre Francois Baclesse; Oncologie, Caen

21000

Centre Georges François Leclerc, Dijon

28007

Hospital General Universitario Gregorio Marañon; Servicio de Oncologia, Madrid

28040

Fundacion Jimenez Diaz; Servicio de Oncologia, Madrid

28050

Centro Integral Oncologico Clara Campal (CIOCC); Dirección Médica, Madrid

31059

Institut Claudius Regaud; Departement Oncologie Medicale, Toulouse

33011

Hospital Univ. Central de Asturias; Servicio de Oncologia, Oviedo

33076

Institut Bergonie; Oncologie, Bordeaux

37007

Hospital Clinico Universitario de Salamanca; Servicio de Oncologia, Salamanca

37232

Vanderbilt, Nashville

44805

Centre Rene Gauducheau, Saint-Herblain

45122

Universitätsklinikum Essen; Innere Klinik und Poliklinik für Tumorforschung, Essen

46010

Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia

48201

Karmanos Cancer Institute, Detroit

50937

Klinik der Uni zu Koeln; Klinik I für Innere Medizin; Onkologie, Cologne

63110

Washington University, St Louis

68167

Universitätsklinikum Mannheim, Tagestherapiezentrum, Interdisziplinäres Tumorzentrum, Mannheim

69373

Centre Leon Berard; Departement Oncologie Medicale, Lyon

77030

University of Texas M.D. Anderson Cancer Center, Houston

80012

Rocky Mountain Cancer Centers, LLP, Aurora

85704

Arizona Oncology, Tucson

94805

Institut Gustave Roussy; Sitep, Villejuif

98902

Yakima Valley Memorial Hospital/North Star Lodge, Yakima

300060

Tianjin Cancer Hospital, Tianjin

02114

Massachusetts General Hospital;Oncology, Boston

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

Unknown

Memorial Sloan-Kettering Cancer Center, New York

08003

Hospital del Mar; Servicio de Oncologia, Barcelona

08035

Hospital Univ Vall d'Hebron; Servicio de Oncologia, Barcelona

AB25 2ZN

Aberdeen Royal Infirmary, Aberdeen

SW3 5PT

The Royal Marsden Hospital; Dept of Medicine, London

SM2 5PT

The Royal Marsden Hospital, Sutton

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01524978 - A Study of Vemurafenib in Participants With BRAF V600 Mutation-Positive Cancers | Biotech Hunter | Biotech Hunter