Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

6

Participants

Timeline

Start Date

February 29, 2012

Primary Completion Date

May 31, 2014

Study Completion Date

September 30, 2015

Conditions
Autoimmune Autonomic Ganglionopathy (AAG)
Interventions
DRUG

Double blinded IVIg

Participants will receive study treatment with IVIg, at 2.0 gm/kg over 2-4 consecutive days. A maintenance study treatment IVIg, at 1.0 gm/kg, over 1-2 consecutive days will occur three weeks later. All participants will proceed to the single blind Second Observation Period.

OTHER

Double blinded Placebo

Participants will receive placebo (5% albumin) at 2.0 gm/kg over 2-4 consecutive days. A maintenance treatment with placebo (5% albumin) at 1.0 gm/kg, over 1-2 consecutive days will occur three weeks later. All participants will proceed to the single blind Second Observation Period.

OTHER

Single Blinded IVIg

This is the single blind Second Observation Period. All participants will receive study treatment with IVIg, at 2.0 gm/kg over 2-4 consecutive days. A maintenance study treatment at 1.0 gm/kg, over 1-2 consecutive days will occur three weeks later.

Trial Locations (6)

10016

NYU Medical Center, New York

20895

Nih Ninds, Bethesda

37215

Vanderbilt University, Nashville

55905

Mayo Clinic, Rochester

75390

UT Southwestern Medical Center, Dallas

02215

Beth Israel Deaconess Medical Center, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Mayo Clinic

OTHER

collaborator

Vanderbilt University

OTHER

collaborator

NYU Langone Health

OTHER

collaborator

University of Texas Southwestern Medical Center

OTHER

collaborator

National Institute of Neurological Disorders and Stroke (NINDS)

NIH

lead

Beth Israel Deaconess Medical Center

OTHER

NCT01522235 - Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy | Biotech Hunter | Biotech Hunter