Effect of Increased Free Fatty Acids on Leptin Function

NACompletedINTERVENTIONAL
Enrollment

26

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

December 31, 2013

Study Completion Date

December 31, 2016

Conditions
ObesityLeptin Resistance
Interventions
DRUG

Saline

IV saline at 0.83 mL/kg/hr for six hours

DRUG

Intralipid

Intralipid in either low-dose or high dose (10% vs. 20%) at 0.83 mL/kr/hr for six hours

DIETARY_SUPPLEMENT

Water

Water by mouth

DIETARY_SUPPLEMENT

oral fat

Soybean oil by mouth at 1.25 g/kg x 2 doses

DRUG

Heparin

Heparin bolus of 1000 units followed by 800 u/hr, adjust per partial thromboplastin time (PTT), for 5.5 hours

Trial Locations (1)

02215

Beth Israel Deaconess Medical Center, Boston

All Listed Sponsors
lead

Beth Israel Deaconess Medical Center

OTHER

NCT01520454 - Effect of Increased Free Fatty Acids on Leptin Function | Biotech Hunter | Biotech Hunter