Drug-drug Interaction Study of Tivantinib (ARQ 197) With Omeprazole, S-warfarin, Caffeine, Midazolam, and Digoxin in Cancer Subjects

three oral 120 mg tablets administered twice a day

One 40 mg oral capsule once alone and once again with tivantinib

One 10 mg oral tablet once alone and once again with tivantinib

One 200 mg oral tablet once alone and once again with tivantinib

One oral 5 mg tablet on multiple days when and around warfarin administration

One oral 0.25 mg tablet once alone and once again with tivantinib

Intravenous 1.5 mg dose once alone and once again with tivantinib