Effectiveness of 3,4-Diaminopyridine in Lambert-Eaton Myasthenic Syndrome

PHASE2CompletedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

January 31, 2012

Primary Completion Date

February 28, 2014

Study Completion Date

July 31, 2015

Conditions
Lambert-Eaton Myasthenic SyndromeEaton-Lambert Myasthenic Syndrome
Interventions
DRUG

Continuous 3,4-DAP

Subjects were maintained on their usual personal dose and schedule of 3,4-DAP base

DRUG

Taper 3,4-DAP to Placebo

Subjects were tapered over 3 days from their usual regimen of 3,4-DAP base to placebo with up to an additional 16 hours of placebo before resuming their usual pre-study regimen of 3,4-DAP base

Trial Locations (7)

27710

Duke University, Durham

37232

Vanderbilt University Medical Center, Nashville

46202

Indiana University, Indianapolis

77030

Baylor College of Medicine, Houston

84132

University of Utah, Salt Lake City

95817

University of California at Davis, Sacramento

97239

Oregon Health & Science University, Portland

Sponsors
All Listed Sponsors
lead

Jacobus Pharmaceutical

INDUSTRY