112
Participants
Start Date
May 20, 2013
Primary Completion Date
March 30, 2020
Study Completion Date
March 30, 2020
Transcranial Direct Current Stimulation
Transcranial Direct Current Stimulation (tDCS), a type of Non-invasive Brain Stimulation (NIBS), has the potential to modify neuronal circuits by application of a subthreshold conductive current through the scalp. Two potential targets for tDCS as a smoking cessation aid are the dorsolateral pre-frontal cortex (dlPFC), a node of the ECN, and the ventromedial prefrontal cortex (vmPFC), a node of the DMN. tDCS can potentially strengthen the control of the ECN through excitatory stimulation of the dlPFC, and weaken the influence of the DMN (Lerman et al 2014) by inhibitory stimulation of the vmPFC. The tDCS model we will use is the neuroConn DC-Stimulator MR (neuroCare Group GmbH, Munchen, Germany).
sham
Sham Comparator
Nicotine patch
Dose-match Nicotine for non-deprived scan
Placebo patch
Nicotine deprived
Varenicline Pill
Treatment
Placebo pill
Active comparator to varenicline
Motivational Interviewing
Motivational Interviewing for smoking cessation preparation
National Institute on Drug Abuse, Baltimore
National Institute on Drug Abuse (NIDA)
NIH