The Effects of Ranolazine on Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction

NACompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

February 28, 2011

Primary Completion Date

December 31, 2014

Study Completion Date

January 31, 2015

Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
DRUG

Ranolazine

Patients with be given 500 mg by mouth twice a day for three days, and then the dose will be increased to 1000 mg by mouth twice daily thereafter. (patients who concurrently take moderate CYP3A inhibitors including diltiazem, verapamil, aprepitant, erythromycin, and fluconazole will continue to 500 mg by mouth twice a day for the entire dosing period)

DRUG

Placebo

Patients will be given 1 tab twice a day for 3 days, then increasing to 2 tabs twice a day thereafter (patients who concurrently take moderate CYP3A inhibitors, will be given 1 tab twice daily for the entire dosing period)

Trial Locations (1)

92037

University of California, San Diego, San Diego

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

University of California, San Diego

OTHER