Phase 1/2 Lyme Vaccine Study

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

1,630

Participants

Timeline

Start Date

March 1, 2011

Primary Completion Date

September 13, 2011

Study Completion Date

February 28, 2014

Conditions
Prophylaxis of Lyme Borreliosis
Interventions
BIOLOGICAL

Multivalent recombinant OspA Lyme Borreliosis Vaccine

Primary vaccination (6 study arms of 50 subjects each): 3 intramuscular injections containing either dose A, B or C in an adjuvanted or non-adjuvanted formulation (6 different formulations) given in monthly intervals (recruited in 3 sequential cohorts)

BIOLOGICAL

Multivalent recombinant OspA Lyme Borreliosis Vaccine

Booster vaccination 9-12 months after first vaccination in Section 1 subjects

BIOLOGICAL

Multivalent recombinant OspA Lyme Borreliosis Vaccine

3 intramuscular injections at monthly intervals (using 2 formulations selected from Section 1) in seronegative and seropositive subjects (N=350) and a booster vaccination at 6 months or at 9-12 months (Cohorts 4: seronegatives; Cohort 5: seropositives)

Trial Locations (8)

1090

Medical University Vienna, Dept. of Clinical Pharmacology, Vienna

Zentrum für Reisemedizin (Center for Travel Medicine), Vienna

10117

Berliner Centrum für Reise- und Tropenmedizin GmbH (BCRT), Berlin

55116

Internistische Gemeinschaftspraxis (Internal Medicine Group Practice), Mainz

63110

Innomed Dr. Naudts Klinische Forschung, Rodgau

72074

Universitätsklinikum Tübingen, Abtlg. Tropenmedizin, Tübingen

79117

Hautarztpraxis Cutanis (Dermatologist), Freiburg im Breisgau

01307

GWT-TUD GmbH, Dresden

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Baxter Innovations GmbH

INDUSTRY

lead

Baxalta now part of Shire

INDUSTRY

NCT01504347 - Phase 1/2 Lyme Vaccine Study | Biotech Hunter | Biotech Hunter