Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant

PHASE3CompletedINTERVENTIONAL
Enrollment

292

Participants

Timeline

Start Date

March 21, 2013

Primary Completion Date

December 31, 2019

Study Completion Date

September 30, 2021

Conditions
Fungal InfectionHematopoietic and Lymphoid Cell Neoplasm
Interventions
DRUG

Caspofungin Acetate

Given IV

DRUG

Fluconazole

Given IV or PO

OTHER

Laboratory Biomarker Analysis

Optional correlative studies

DRUG

Voriconazole

Given IV or PO

Trial Locations (49)

10467

Montefiore Medical Center - Moses Campus, The Bronx

14263

Roswell Park Cancer Institute, Buffalo

15224

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

Children's Hospital of Philadelphia, Philadelphia

19803

Alfred I duPont Hospital for Children, Wilmington

27599

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

27710

Duke University Medical Center, Durham

30322

Children's Healthcare of Atlanta - Egleston, Atlanta

32207

Nemours Children's Clinic-Jacksonville, Jacksonville

33701

Johns Hopkins All Children's Hospital, St. Petersburg

37232

Vanderbilt University/Ingram Cancer Center, Nashville

39216

University of Mississippi Medical Center, Jackson

40202

Norton Children's Hospital, Louisville

43205

Nationwide Children's Hospital, Columbus

44106

Rainbow Babies and Childrens Hospital, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

44308

Children's Hospital Medical Center of Akron, Akron

46202

Riley Hospital for Children, Indianapolis

48109

C S Mott Children's Hospital, Ann Arbor

48201

Wayne State University/Karmanos Cancer Institute, Detroit

49503

Helen DeVos Children's Hospital at Spectrum Health, Grand Rapids

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Children's Hospital of Wisconsin, Milwaukee

55455

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

64108

Children's Mercy Hospitals and Clinics, Kansas City

68114

Children's Hospital and Medical Center of Omaha, Omaha

68198

University of Nebraska Medical Center, Omaha

70118

Children's Hospital New Orleans, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75230

Medical City Dallas Hospital, Dallas

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

78229

Methodist Children's Hospital of South Texas, San Antonio

84113

Primary Children's Hospital, Salt Lake City

85016

Phoenix Childrens Hospital, Phoenix

92123

Rady Children's Hospital - San Diego, San Diego

92354

Loma Linda University Medical Center, Loma Linda

92868

Children's Hospital of Orange County, Orange

94143

UCSF Medical Center-Parnassus, San Francisco

94158

UCSF Medical Center-Mission Bay, San Francisco

94304

Lucile Packard Children's Hospital Stanford University, Palo Alto

96813

University of Hawaii Cancer Center, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

94609-1809

Children's Hospital and Research Center at Oakland, Oakland

02111

Floating Hospital for Children at Tufts Medical Center, Boston

07601

Hackensack University Medical Center, Hackensack

T3B 6A8

Alberta Children's Hospital, Calgary

R3E 0V9

CancerCare Manitoba, Winnipeg

M5G 1X8

Hospital for Sick Children, Toronto

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

Children's Oncology Group

NETWORK

NCT01503515 - Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant | Biotech Hunter | Biotech Hunter