Phase 3 Study of Sofosbuvir and Ribavirin

PHASE3CompletedINTERVENTIONAL
Enrollment

527

Participants

Timeline

Start Date

December 31, 2011

Primary Completion Date

January 31, 2013

Study Completion Date

April 30, 2013

Conditions
Hepatitis C
Interventions
DRUG

Sofosbuvir

Sofosbuvir 400 mg (2 × 200 mg tablets) administered orally once daily

DRUG

PEG

Pegylated interferon alfa-2a (PEG) 180 μg administered once weekly by subcutaneous injection

DRUG

RBV

"Ribavirin (RBV) administered as 200 mg tablets up to 1200 mg in a divided daily dose~* Dose of sofosbuvir+RBV group based on baseline weight: \< 75kg = 1000 mg and ≥ 75 kg = 1200 mg~* Dose of PEG+RBV group: 800 mg"

Trial Locations (97)

2050

Royal Prince Alfred Hospital, Camperdown

2137

Concord Repatriation General Hospital, Concord

2217

St. George Hospital, Kogarah

2605

Canberra Hospital, Garran

3004

The Alfred, Melbourne

3084

Austin Hospital, Heidelberg

3143

Tauranga Hospital, Tauranga

3168

Monash Medical Centre, Clayton

3240

Waikato Hospital (District Health Board), Hamilton

4029

Royal Brisbane Hospital Research Foundation, Herston

4102

Princess Alexandria, Woollongabba

4120

Gallipoli MRF, Greenslopes

5000

Royal Adelaide Hospital, Adelaide

6000

Royal Perth Hospital, Perth

6009

Sir Charles Gairdner, Nedlands

6021

Wellington Hospital, Newtown

6160

Fremantle Hospital, Fremantle

8001

Christchurch Hospital, Chrischurch

9010

Mercy Hospital, Dunedin

10021

Weill Cornell Medical College, New York

10029

Mount Sinai School of Medicine, New York

11030

North Shore University Hospital, Manhasset

14662

University of Rochester, Rochester

15213

UPMC Center For Liver Diseases, Pittsburgh

17604

Regional Gastroenterology Associates of Lancaster, Ltd., Lancaster

21229

Digestive Disease Associates, P.A., Baltimore

22031

Metropolitan Research, Fairfax

23502

Digestive and Liver Disease Specialist, Ltd., Norfolk

Digestive and Liver Disease Specialists, Norfolk

27103

Digestive Health Specialists, PA, Winston-Salem

27710

Duke University Medical Center, Durham

28677

Carolinas Center for Liver Disease, Statesville

28801

Asheville Gastroenterology Associates, P.A., Asheville

30060

Gastrointestinal Specialists of Georgia, PC, Marietta

30308

AIDS Research Consortium of Atlanta, Inc., Atlanta

Atlanta Gastroenterology Associates, Atlanta

32256

Borland-Groover Clinic Baptist, Jacksonville

32610

University of Florida College of Medicine, Gainesville

32803

Orlando Immunology Center, Orlando

32806

Internal Medicine Specialists, Orlando

33136

University of Miami, School of Medicine, Miami

33414

South Florida Center of Gastroenterology, Wellington

34209

Pointe West Infectious Diseases, Bradenton

34655

Advanced Research Institute, Trinity

34982

Midway Immunology & Research Center, LLC, Ft. Pierce

35294

University of Alabama at Birmingham, Birmingham

36116

Alabama Liver & Digestive Specialist, Montgomery

37211

Nashville Gastrointestinal Specialists Inc., Nashville

38138

Gastro One, Germantown

38801

Digestive Health Specialists, PA, Tupelo

41685

Sahlgrenska Universitetssjukhuset, Östra Sjukhus, Gothenburg

45267

University of Cincinnati, Cincinnati

46237

Indianapolis Gastroenterology Research Foundation, Indianapolis

48202

Henry Ford Health System, Detroit

60637

University of Chicago, Chicago

71013

Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo

74135

Gastroenterology United of Tulsa, Tulsa

75246

Baylor University Medical Center, Dallas

76012

Texas Clinical Research Institute, LLC, Arlington

77005

Kelsey-Seybold Clinic PA, Houston

77030

Research Specialists of Texas, Houston

VAMC & Baylor College, Houston

78215

Alamo Medical Research, San Antonio

80113

South Denver Gastroenterology, PC, Englewood

87505

Southwest C.A.R.E. Center, Santa Fe

90036

Peter J. Ruane, M.D. Inc., Los Angeles

90210

California Liver Institute, Beverly Hills

91940

eStudy Site, La Mesa

92056

eStudySite, Oceanside

92103

University of California San Diego Medical Center, San Diego

92105

Research and Education, Inc., San Diego

92118

SCTI Research Foundation, Coronado

92123

Medical Associates Research Group, Inc., San Diego

92324

Arrowhead Regional Medical Center, Colton

93301

Franco Felizarta, MD, Bakersfield

94115

Quest Clinical Research, San Francisco

95817

University of California, Davis - Health System, Sacramento

97504

Schleinitz Research and Gastroenterology LLC, Medford

98101

Virginia Mason Medical Center, Seattle

02115

Beth Israel Deaconess Medical Center, Boston

01105

The Research Institute, Springfield

01608-1320

Partners in Internal Medicine, PC, Worcester

01655

University of Massachusetts, Worcester, Worcester

07018

Veterans Affairs Medical Center, East Orange

08234

AGA Clinical Research Associates, LLC, Egg Harbor

08844

ID Care, Hillsborough

07960

Atlantic Research Affiliates, LLC, Morristown

02886

University Gastroenterology, Warwick

V6Z 2K5

(G.I.R.I.) Gastrointestinal Research Institute, Vancouver

M5G 1X5

Mount Sinai Hospital, Toronto

M5G 2N2

University Health Network-Toronto Western Hospital, Toronto

M6H 3M1

Toronto Liver Centre, Toronto

L4L 4Y7

Toronto Digestive Disease Associates, Inc., Vaughan

1105 AZ

Academish Medisch Centrum, Amsterdam

Unknown

Auckland City Hospital, Grafton

00927

Fundacion de Investigacion de Diego, San Juan

171 76

Karolinska Universitetssjukhuset, Solna, Stockholm

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY

NCT01497366 - Phase 3 Study of Sofosbuvir and Ribavirin | Biotech Hunter | Biotech Hunter