The Safety, Tolerability, PK and PD of GSK2339345 in Healthy Subjects

3, 6, 15, 30, 60 and 120 micrograms (proposed doses). 2 alternating cohorts of 6 subjects. Each subject to receive 3 ascending doses with washout of at least 48 hours between doses. Rinse, Gargle and Spit.

25, 100, 250, 1000 and 2000 micrograms (proposed doses). Subjects randomised to receive three ascending doses (with each dose given on two consecutive days). Washout of at least 6 days between treatment periods. Nebulised.

Administered on Day 1 of one of the treatment periods in part B. Randomised. Nebulised.

40mg dose. Administered on Day 2 of one of the treatment periods in part B. Randomised. Nebulised.