2
Participants
Start Date
April 30, 2012
Primary Completion Date
October 31, 2015
Study Completion Date
October 31, 2015
DNA Vaccine
Patients will receive intramuscular needle injections of pNGVL4a-CRT/E7 (detox) DNA vaccine using the TDS-IM device on Day 1, 22, and 43 for a total of three vaccinations per patient. One day prior to each DNA vaccination, the patient will receive a single low dose of 200 mg/m2 of cyclophosphamide intravenously. The DNA vaccine will be administered in a dose-escalating manner.
Cyclophosphamide
A single low dose of 200 mg/m2 of cyclophosphamide (CTX) will be administered intravenously up to 24 hours (Day 0) prior to each DNA vaccination.
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore
Collaborators (1)
National Institute of Dental and Craniofacial Research (NIDCR)
NIH
Ichor Medical Systems Incorporated
INDUSTRY
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
OTHER