258
Participants
Start Date
February 17, 2012
Primary Completion Date
March 17, 2016
Study Completion Date
November 14, 2019
Pertuzumab
Participants will receive a loading dose of 840 milligrams (mg) as an intravenous infusion on Day 1 of first treatment cycle, followed by 420 mg on Day 1 or Day 2 of each subsequent 3-week cycle until disease progression or unacceptable toxicity.
Trastuzumab
Participants will receive a loading dose of 8 milligrams per kilogram (mg/kg) as an intravenous infusion on Day 1 or 2 of first treatment cycle, followed by 6 mg/kg on Day 1 or Day 2 of each subsequent treatment 3-week cycles until disease progression or unacceptable toxicity.
Aromatase Inhibitor
Participants will receive 1 mg anastrozole or 2.5 mg letrozole orally once daily.
Induction Chemotherapy
Participants receiving induction chemotherapy up to the first 18-24 weeks of the treatment period will receive a taxane (docetaxel every 3 weeks or paclitaxel weekly), administered in line with the respective pertuzumab and/or trastuzumab infusions at the investigator's discretion.
Hospital de San Pedro de Alcantara, Cáceres
NS-Long Island Jewish Hlth Sys, Lake Success
ProHEALTH Care Associates LLP, Lake Success
Hospital Provincial de Castellon; Servicio de Oncologia, Castellon
Hospital Universitario Reina Sofia; Servicio de Oncologia, Córdoba
Complejo Hospitalario Universitario A Coruña (CHUAC, Materno Infantil), Oncología, A Coruña
Centro Oncológico Gallego José Antonio Quiroga y Piñeiro, Servicio de Oncologia, A Coruña
UPMC Cancer Centers, Pittsburgh
IInstituto Oncologico de San Sebastian, Oncologikoa; Servicio de Oncologia, Donostia / San Sebastian
Hospital de Donostia; Servicio de Oncologia Medica, Donostia / San Sebastian
Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1, Milan
Center For Cancer and Blood Disorders, Bethesda
Casa di Cura MultiMedica Ospedale di Castellanza; UO Senologia Medica, Castellanza
Weinberg CA Inst Franklin Sq, Baltimore
HOPITAL JEAN MINJOZ; Oncologie, Besançon
Hospital Universitari Arnau de Vilanova de Lleida; Servicio de Oncologia, Lleida
IRCCS Fondazione Maugeri; Oncologia Medica I, Pavia
Hospital Ramon y Cajal; Servicio de Oncologia, Madrid
Hospital Universitario Clínico San Carlos; Servicio de Oncologia, Madrid
Hopital Morvan; Oncologie - Radiotherapie, Brest
Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Marietta
Hospital Universitario Virgen de Arrixaca; Servicio de Oncologia, Murcia
Georgia Cancer Specialists - Northside, Atlanta
Clinique Pasteur; Oncologie Medicale, Toulouse
Clinique Tivoli; Sce Radiotherapie, Bordeaux
A.O. Santa Maria Degli Angeli; U.O Di Oncologia Medica, Pordenone
Advanced Medical Specialties, Miami
Ege Uni Medical Faculty Hospital; Oncology Dept, Izmir
University of Alabama at Birmingham, Birmingham
Azienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica, Bologna
Hospital Universitario Virgen Macarena; Servicio de Oncologia, Seville
Ospedale Regionale Di Parma; Divisione Di Oncologia Medica, Parma
Centre Catherine de Sienne; Chimiotherapie, Nantes
Inonu University Medical Faculty Turgut Ozal Medical Center Medical Oncology Department, Malatya
Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia, Valencia
Hospital Universitario Miguel Servet; Servicio Oncologia, Zaragoza
A.O. Careggi; Radioterapia, Florence
Centre Alexis Vautrin; Oncologie Medicale, Vandœuvre-lès-Nancy
Ospedale Misericordia E Dolce; Oncologia Medica, Prato
CH De Senlis; Medecine 2, Senlis
Centre Jean Perrin; Oncologie, Clermont-Ferrand
Washington University School of Medicine; Internal Medicine - Renal, St Louis
Clinique De La Sauvegarde; Chimiotherapie, Lyon
Crescent City Rsrch Cnsrtm, LLC, Marrero
Irccs Ist. Tumori Giovanni Paolo Ii; Dipartimento Oncologia Medica, Bari
Genesis Cancer Center, Hot Springs
Ospedale Antonio Perrino; Oncologia Medica, Brindisi
Ospedale Vito Fazzi; Div. Oncoematologia, Lecce
Scott and White Hospital; Cancer Center, Temple
Baylor College of Medicine; Lester & Sue Smith Breast Ctr, Houston
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli
Università degli Studi Federico II; Clinica di Oncologia Medica, Napoli
Rocky Mountain Cancer Center - Denver, Denver
Ironwood Cancer TX & Rsch Ctrs, Chandler
Comprehensive Blood & CA Ctr; Research, Bakersfield
Az Ospedaliera Nuovo Garibaldi Quartiere Nesima; Oncologia Medica, Catania
Indraprastha Apollo Hospitals, New Delhi
Jaslok Hospital & Research Centre; Medical Oncology, Mumbai
Bangalore Institute of Oncology, Bangalore
Apollo Speciality Hospital, Chennai
Norwalk Hospital, Norwalk
Cancer Center of Kansas, Wichita
Hematology Oncology Associates; Carol G. Simon Ctr, Morristown
Cooper Hospital; Hematology & Oncology, Voorhees Township
Instituto do Cancer do Estado de Sao Paulo - ICESP, São Paulo
Hospital Perola Byington, São Paulo
Inst. Brasileiro de Controle Ao Cancer; Oncologia Clinica / Quimioterapia, São Paulo
Hospital Sao Jose, São Paulo
Centre Antoine Lacassagne; Hopital De Jour A2, Nice
Ruby Hall Clinic, Pune
Ospedale S.S. Trinità Nuovo; Divisione Oncologia, Sora
Hospital Universitari Germans Trias i Pujol; Servicio de Oncologia, Badalona
Hospital del Mar; Servicio de Oncologia, Barcelona
Hacettepe Uni Medical Faculty Hospital; Oncology Dept, Ankara
Ankara City Hospital, Ankara
Brighton and Sussex Univ Hosp, Brighton
University Hospital coventry; Oncology Department, Coventry
Beatson West of Scotland Cancer Centre, Glasgow
Queen Elizabeth Hospital, London
Queen Alexandra Hospital, Portsmouth, Portsmouth
Scarborough General Hospital, Scarborough
Weston Park Hospital; Cancer Clinical Trials Centre, Sheffield
Hoffmann-La Roche
INDUSTRY