A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC)

PHASE2CompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

January 31, 2012

Primary Completion Date

July 31, 2015

Study Completion Date

July 31, 2015

Conditions
Colorectal Cancer
Interventions
DRUG

Axitinib

5-mg tablets PO BID

DRUG

Bevacizumab

5 mg/kg Days 1 and 15; IV

DRUG

5-Fluorouracil

400 mg/m2 Days 1 and 15; IV

DRUG

5-Fluorouracil

2400 mg/m2 over 46-48 hours Days 1 and 15; Continuous Intravenous

DRUG

Leucovorin

400 mg/m2 Days 1 and 15; IV

DRUG

Oxaliplatin

85 mg/m2 Days 1 and 15; IV

Trial Locations (12)

30501

Northeast Georgia Medical Center, Gainesville

32503

Woodlands Medical Specialists, Pensacola

33705

Florida Cancer Specialists-North, St. Petersburg

33916

Florida Cancer Specialists-South, Fort Myers

37203

Tennessee Oncology, Nashville

47630

Oncology Hematology of SW Indiana, Newburgh

47802

Hope Cancer Center, Terre Haute

49503

Grand Rapids Oncology Program, Grand Rapids

68114

Nebraska Methodist Hospital, Omaha

72401

NEA Baptist Clinic, Jonesboro

75243

Texas Health Physician Group, Dallas

07901

Atlantic Health System, Summit

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

SCRI Development Innovations, LLC

OTHER

NCT01490866 - A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC) | Biotech Hunter | Biotech Hunter