Relative Bioavailability and Food Effect Study

PHASE1CompletedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

January 31, 2012

Primary Completion Date

April 30, 2012

Study Completion Date

May 31, 2012

Conditions
Pharmacology, Clinical
Interventions
DRUG

Riociguat (BAY63-2521)

Single oral dose of 2.4 milligram (mg) riociguat (BAY63-2521) as pediatric high-concentration suspension (0.15 mg per milliliter \[mg/mL\], i.e. 16 mL) under fasting conditions

DRUG

Riociguat (BAY63-2521)

Single oral dose of 2.4 mg riociguat as pediatric high-concentration suspension (0.15 mg/mL, i.e. 16 mL) under fed conditions

DRUG

Riociguat (BAY63-2521)

Single oral dose of 0.3 mg riociguat as pediatric high-concentration suspension (0.15 mg/mL, i.e. 2 mL) under fasting conditions

DRUG

Riociguat (BAY63-2521)

Single oral dose of 0.15 mg riociguat as pediatric low-concentration suspension (0.03 mg/mL, i.e. 5 mL) under fasting conditions

DRUG

Riociguat (BAY63-2521)

Single oral dose of riociguat immediate release (IR) tablet 1 mg under fasting conditions

Trial Locations (1)

51063

Cologne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY