Safety Study of IL-21/Ipilimumab Combination in the Treatment of Melanoma

PHASE1CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

December 31, 2011

Primary Completion Date

June 30, 2014

Study Completion Date

June 30, 2014

Conditions
Melanoma
Interventions
BIOLOGICAL

BMS-982470 (recombinant interleukin-21)

Solution, Intravenous, 10,30,50 μg/kg, daily for 5 days every 3 weeks (daily x 5), 16-20 weeks depending on response

BIOLOGICAL

BMS-982470 (recombinant interleukin-21)

Solution, Intravenous, 30,100,150 μg/kg, weekly, 16-20 weeks depending on response

BIOLOGICAL

BMS-982470 (recombinant interleukin-21)

Solution, Intravenous, Maximum tolerated dose from Part 1, daily for 5 days every 3 weeks (daily x 5), 12-16 weeks depending on response

BIOLOGICAL

BMS-982470 (recombinant interleukin-21)

Solution, Intravenous, Maximum tolerated dose from Part 1, Weekly, 12-16 weeks depending on response

BIOLOGICAL

Ipilimumab

Solution, Intravenous, 1,3,10 mg/kg, every 3 weeks, 16-20 weeks depending on response

BIOLOGICAL

Ipilimumab

Solution, Intravenous, Maximum tolerated dose from Part 1, every 3 weeks, 12-16 weeks depending on response

BIOLOGICAL

Ipilimumab

Solution, Intravenous, 3mg/kg, Every 3 weeks, 12-16 weeks depending on response

Trial Locations (9)

33612

H. Lee Moffitt Cancer Center & Research Inst, Inc, Tampa

40202

University Of Louisville Medical Center, Inc., Dba, Louisville

46202

Indiana University Health Melvin And Bren Simon Cancer Center, Indianapolis

77030

Md Anderson Can Cnt, Houston

85258

Oncology Research Associates, Pllc D/B/A, Scottsdale

90095

Ucla Hematology/Oncology., Los Angeles

97213

Portland Providence Medical Center, Portland

98109

Seattle Cancer Care Alliance, Seattle

00927

Local Institution, San Juan

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY

NCT01489059 - Safety Study of IL-21/Ipilimumab Combination in the Treatment of Melanoma | Biotech Hunter | Biotech Hunter