62
Participants
Start Date
August 31, 2011
Primary Completion Date
August 31, 2015
Study Completion Date
February 28, 2017
Metformin
Oral administration, 500 mg daily at week 1. Every week metformin dosage increases with 500 mg, to a maximum dose of 1000 mg bid. This maximum dose will be administered till the end of the study.
Lifestyle intervention
Lifestyle intervention: 18 months physical therapy and dietary advice
Jeroen Bosch Hospital, 's-Hertogenbosch
St. Antonius Hospital, Nieuwegein
Jeroen Bosch Ziekenhuis
OTHER
St. Antonius Hospital
OTHER