Trial of Erlotinib and BKM120 in Patients With Advanced Non Small Cell Lung Cancer Previously Sensitive to Erlotinib

PHASE2CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

March 31, 2014

Primary Completion Date

May 31, 2016

Study Completion Date

December 11, 2017

Conditions
Non Small Cell Lung Cancer
Interventions
DRUG

BKM120 and Erlotinib

BKM120 and Erlotinib will be given once daily. Erlotinib 100 mg PO will be administered. During Cycle 1-Week 1 all patients will receive 80 mg PO daily BKM120. After the first week of Cycle 1, the dose of BKM120 will escalate to 100 mg PO daily and treatment will continue as long as there are no unexpected or prohibitive toxicities, or disease progression.

Trial Locations (7)

32804

Florida Hospital Cancer Institute, Orlando

33401

Florida Cancer Specialists East, West Palm Beach

33705

Florida Cancer Specialists North, St. Petersburg

33916

Florida Cancer Specialists South, Fort Myers

37023

Tennessee Oncology, PLLC, Nashville

45242

Oncology Hematology Care, Inc., Cincinnati

76104

Center for Cancer and Blood Disorders, Fort Worth

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

SCRI Development Innovations, LLC

OTHER