Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)

PHASE3CompletedINTERVENTIONAL
Enrollment

171

Participants

Timeline

Start Date

October 31, 2013

Primary Completion Date

November 30, 2018

Study Completion Date

March 31, 2019

Conditions
Familial Adenomatous Polyposis
Interventions
DRUG

Eflornithine

Eflornithine \[250 mg tablet, three tablets (750 mg) orally once a day\]

DRUG

Eflornithine Placebo

Eflornithine placebo \[three tablets orally once a day\]

DRUG

Sulindac 150 MG

Sulindac \[one tablet orally once a day\]

DRUG

Sulindac placebo

Sulindac placebo \[one tablet orally once a day\]

Trial Locations (17)

3000

UZ Leuven, Leuven

19104

University of Pennsylvania, Philadelphia

30322

Emory University, Atlanta

44195

Cleveland Clinic, Cleveland

48109

University of Michigan, Ann Arbor

53105

University Hospital Bonn, Bonn

55905

Mayo Clinic, Rochester

63110

Washington University, St Louis

77030

MD Anderson Cancer Center, Houston

84112

University of Utah- Huntsman Cancer Institute, Salt Lake City

92093

University of California San Diego, La Jolla

02215

Dana Farber Cancer Institute, Boston

M5T 3L9

Zane Cohen Centre For Digestive Diseases, Toronto

1100 DE

Academic Medical Centre, Amsterdam

08036

Institut de Malalties Digestives, Barcelona

NEI 3BZ

Institute of Genetic Medicine, Newcastle upon Tyne

M13 NWL

Manchester Center for Genomic Medicine, Manchester

All Listed Sponsors
lead

Cancer Prevention Pharmaceuticals, Inc.

INDUSTRY