A Study of Mericitabine in Combination With Telaprevir and Peginterferon Alfa-2a / Ribavirin in Participants With Chronic Hepatitis C

PHASE2CompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

January 31, 2014

Study Completion Date

January 31, 2014

Conditions
Hepatitis C
Interventions
DRUG

Ribavirin

Participants will receive a total daily dose of 1000 milligrams (mg) (for participants weighing less than \[\<\] 75 kg) or 1200 mg (for participants weighing greater than or equal to \[\>=\] 75 kg) orally for 24 or 48 weeks.

DRUG

Mericitabine

Participants will receive mericitabine 1000 mg orally twice daily.

DRUG

Peginterferon Alfa-2a

Participants will receive 180 micrograms (mcg) subcutaneous injection once weekly.

DRUG

Placebo

Participants will receive placebo matching to mericitabine orally twice daily.

DRUG

Telaprevir

Participants will receive telaprevir 750 mg orally three times daily.

Trial Locations (39)

10021

Weill Cornell Medical College, New York

13285

Fondation Hopital Saint Joseph; Gastro-Enterologie, Marseille

20162

ASST GRANDE OSPEDALE METROPOLITANO NIGUARDA; Divisione Malattie Infettive, Milan

21093

John Hopkins Hospital, Lutherville

23249

McGuire; Veteran Affairs Med Ctr, Richmond

24105

Universitäts Klinikum; Schleswig-Holstein Kiel, Kiel

28029

Hospital Carlos III; Laboratorio de Biologia Molecular, Madrid

28677

Carolina'S Center For Liver Disease, Statesville

31059

Hopital Purpan;Gastro Enterologie Hepatologie, Toulouse

34102

Gastroenterology Group of Naples, Naples

35209

Birmingham Gastro Associates, P.C., Birmingham

38320

Hospital Universitario de Canarias; Servicio de Digestivo, San Cristóbal de La Laguna

40138

UNI DEGLI STUDI - POLICLINICA S. ORSOLA; Dipartimento Malattie dell'Apparato Digerente e Medicina In, Bologna

56124

Ospedale Cisanello - Az. Osp. Pisana; Unità Operativa Di Gastroenterologia Ed Epatologia, Pisa

59037

Hopital Claude Huriez;Gastro Enterologie, Lille

60590

Klinik Johann Wolfgang von Goethe Uni; Zentrum der Inneren Medizin; Medizinische Klinik I, Frankfurt am Main

63104

Saint Louis University Gastroenterology & Hepatology; Clinical Research Unit, St Louis

75246

Baylor Uni Medical Center; Division Of Hepatology/Transplantation; Annette C. and Harold C. Simmons, Dallas

79106

Uniklinik Freiburg; Abteilung Innere Medizin II, Freiburg im Breisgau

90822

VA Long Beach Healthcare System, Long Beach

92103

UCSD Antiviral Research Center, San Diego

95825

Kaiser Permanente Sacramento Medical Center, Sacramento

98104

Harborview Medical Center, Seattle

06510

Yale University, New Haven

01702

Metrowest Medical Center, Framingham

45267-0595

Uni of Cincinnati College of Medicine; Div. of Digestive Diseases, Cincinnati

V5Z 1M9

Gordon & Leslie Diamond Health Care Centre; Dept. of Medicine - Division of Gastroenterology, Vancouver

V6Z 2K5

GI Research Institute; Gastroenterology & Hepatology, Vancouver

V8V 3P9

Percuro Clinical Research Ltd., Victoria

R3A 1R9

Winnipeg Regional Health Authority; Section of Hepatology, Winnipeg

M5G 1L7

University Health Network - Toronto Western Hospital; Hepatology, Toronto

L4L 4Y7

Toronto Digest. Disease Asso., Woodbridge

H2X2P4

McGill University, Montreal Chest Institute; Viral and other Infectious, Montreal

08035

Hospital Universitari Vall d'Hebron; Departamento de Enfermedades Infecciosas, Barcelona

08036

Hospital Clinic I Provincial; Servicio de Digestivo, Barcelona

BH7 7DW

Royal Bournemouth Hospital, Gastroenterology, Dorset

SE5 9RS

King'S College Hospital; Institute of Liver Studies, London

SW17 0QT

St George's Hospital, London

W2 1NY

Imperial College Healthcare NHS Trust; Hepatology Clinical Research Facility, London

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01482390 - A Study of Mericitabine in Combination With Telaprevir and Peginterferon Alfa-2a / Ribavirin in Participants With Chronic Hepatitis C | Biotech Hunter | Biotech Hunter