Ofatumumab With IVAC Salvage Chemotherapy in Diffuse Large B Cell Lymphoma Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

77

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

July 31, 2017

Study Completion Date

December 31, 2018

Conditions
Diffuse Large B Cell Lymphoma
Interventions
DRUG

Ofatumumab

1000 IV, according to detailed instruction included in the protocol, on day 1 of each 21-day cycle, maximum 6 cycles

DRUG

Etoposide

60mg/m2 IV, daily over 1 hour, on days 1-5 of 21-day cycle, maximum 6 cycles

DRUG

Ifosfamid

1500mg/m2 or 1000mg/m2 (patients \>/=60 years), IV, daily over 1 hour, on 1-5 days of each 21-day cycle, maximum 6 cycles

DRUG

Mesna

300mg/m2 or 200mg/m2 (patients \>/=60 years), IV, over 1 hour, mixed with ifosfamid then 900mg/m2 or 600mg/m2 (patients \>/=60 years)over 12 hour or by local practice, on 1-5 days of each 21 day cycle, maximum 6 cycles

DRUG

Cytarabine

2g/m2 or 0,5-1g/m2 (patients \>/= 60 years), IV, over 3 hours, 12 hourly (total of 4 doses), on days 1-2 of each 21 day cycle, maximum 6 cycles

DRUG

Methotrexate

12mg, it, on day 5 of each 21 days cycle, maximum 6 cycles

DRUG

Leukovorin

15mg, po 24 hours after methotrexate it

DRUG

Granulocyte-Colony Stimulating Factor

5 microgram/kg or 263 microgram ampoule, sc, daily, starting on day 7 of each 21 day cycle, until ANC\>1.0x109/l

Trial Locations (8)

53-439

Dolnośląskie Centrum Transplantacji Komórkowych, Wroclaw

02-776

Instytut Hematologii i Transfuzjologii, Warsaw

02-781

Centrum Onkologii - Istytut im. M.Sklodowskiej-Curie, Warsaw

16-200

Szpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im. ks. Bronisława Markiewicza, Brzozów

80-952

Uniwersyteckie Cenrum Medyczne, Gdansk

81-519

Szpital Morski im. PCK Oddz. Onkologii i Radioterapii, Gdynia

44-101

Klinika Transplantacji Szpiku i Onkohematologii; Centrum Onkologii Instytut im. M.Sklodowskiej-Curie, Oddz. w Gliwicach, Gliwice

10-228

Oddz. Hematologii, Samodzielny Publiczny ZOZ MSW z Warminsko-Mazurskim Centrum Onkologii w Olsztynie, Olsztyn

All Listed Sponsors
lead

Polish Lymphoma Research Group

NETWORK

NCT01481272 - Ofatumumab With IVAC Salvage Chemotherapy in Diffuse Large B Cell Lymphoma Patients | Biotech Hunter | Biotech Hunter