150
Participants
Start Date
December 12, 2011
Primary Completion Date
March 7, 2013
Study Completion Date
March 7, 2013
Pregabalin
150mg (2hrs) pre operatively and twice daily post operatively for 10 days, followed by dose reduction to 75mg twice daily for 2 days and finally to 50 mg twice daily for 2 days
Ketamine infusion
0.1mg/kg/hr for 48 hours post operatively
Placebo capsules
Single capsule (2hrs) pre operatively and twice daily post operatively for 10 days, followed by dose reduction to single capsule twice daily for 2 days and finally to single capsule twice daily for 2 days
Placebo infusion
Normal saline placebo intravenous infusion for 48 hours
Pain and Ananesthesia Research Centre, Barts and The London NHS Trust, London
Barts & The London NHS Trust
OTHER