A Study of the Effectiveness and Safety of Different Doses of Fluticasone Propionate Taken From a Dry Powder Inhaler in Adolescents and Adults Who Have Asthma That is Not Controlled by Asthma Medications Not Containing Steroids

PHASE2CompletedINTERVENTIONAL
Enrollment

909

Participants

Timeline

Start Date

January 31, 2012

Primary Completion Date

July 31, 2013

Study Completion Date

July 31, 2013

Conditions
Asthma
Interventions
DRUG

Fp MDPI

"Fp MDPI is an inhalation-driven multidose dry powder inhaler (MDPI) containing fluticasone propionate (Fp) dispersed in a lactose monohydrate excipient and contained within a reservoir. A metered dose of drug is delivered to a dose cup via an air pulse activated when the cap is opened.~During the treatment period, participants were randomized to 12.5, 25, 50 or 100 mcg of Fp one inhalation twice a day for a total daily dose of 25, 50, 100 or 200 mcg. Study drug was administered in the morning and in the evening"

DRUG

Flovent Diskus

Flovent Diskus contains the active ingredient fluticasone propionate (Fp). Flovent Diskus 100 mcg was used twice a day, once in the morning and evening, for a total daily dose of 200 mcg of Fp. This therapy was not blinded as the inhaler device was different than the MDPI used in the other treatment arms.

DRUG

albuterol/salbutamol

A short-acting β2-adrenergic agonists (SABA), albuterol/salbutamol hydrofluoroalkane (HFA) metered dose inhaler (MDI), was provided to be used as needed for the relief of asthma symptoms during both the run-in and treatment periods (to replace the subject's current rescue medication).

DRUG

Placebo MDPI

Placebo multidose dry powder inhaler in the morning and evening. Placebo MDPI was provided in devices identical in appearance to Fp MDPI.

Trial Locations (189)

Unknown

Teva Investigational Site 10165, Homewood

Teva Investigational Site 11142, Goodyear

Teva Investigational Site 10104, Scottsdale

Teva Investigational Site 11149, Little Rock

Teva Investigational Site 10173, Bakersfield

Teva Investigational Site 10163, Costa Mesa

Teva Investigational Site 10156, Encinitas

Teva Investigational Site 11101, Fountain Valley

Teva Investigational Site 11111, Fresno

Teva Investigational Site 10151, Granada Hills

Teva Investigational Site 10157, Huntington Beach

Teva Investigational Site 10176, Huntington Beach

Teva Investigational Site 10147, Long Beach

Teva Investigational Site 11110, Napa

Teva Investigational Site 10136, Newport Beach

Teva Investigational Site 11122, North Hollywood

Teva Investigational Site 10140, Orange

Teva Investigational Site 10197, Palmdale

Teva Investigational Site 10185, Redwood City

Teva Investigational Site 10143, Riverside

Teva Investigational Site 11137, Roseville

Teva Investigational Site 10130, San Diego

Teva Investigational Site 10182, San Diego

Teva Investigational Site 10179, San Jose

Teva Investigational Site 10106, Stockton

Teva Investigational Site 10129, Walnut Creek

Teva Investigational Site 10145, Centennial

Teva Investigational Site 10172, Colorado Springs

Teva Investigational Site 10133, Denver

Teva Investigational Site 10154, Denver

Teva Investigational Site 11146, Denver

Teva Investigational Site 10128, Wheat Ridge

Teva Investigational Site 10196, Waterbury

Teva Investigational Site 10191, Boynton Beach

Teva Investigational Site 11127, Brandon

Teva Investigational Site 11118, Clearwater

Teva Investigational Site 11141, Hialeah

Teva Investigational Site 11140, Kissimmee

Teva Investigational Site 10137, Miami

Teva Investigational Site 10153, Miami

Teva Investigational Site 11120, Miami

Teva Investigational Site 11128, Miami

Teva Investigational Site 11132, Miami

Teva Investigational Site 11145, Miami

Teva Investigational Site 10171, Ocala

Teva Investigational Site 10178, Sarasota

Teva Investigational Site 11103, South Miami

Teva Investigational Site 10161, Tallahassee

Teva Investigational Site 10139, Tampa

Teva Investigational Site 11114, Albany

Teva Investigational Site 10111, Columbus

Teva Investigational Site 11124, Columbus

Teva Investigational Site 10180, Gainesville

Teva Investigational Site 10168, Lawrenceville

Teva Investigational Site 11109, Idaho Falls

Teva Investigational Site 10116, Meridian

Teva Investigational Site 10127, South Bend

Teva Investigational Site 10184, Iowa City

Teva Investigational Site 10113, Metairie

Teva Investigational Site 10164, Bangor

Teva Investigational Site 10158, Bethesda

Teva Investigational Site 10110, Largo

Teva Investigational Site 10177, Wheaton

Teva Investigational Site 10138, North Dartmouth

Teva Investigational Site 10146, North Dartmouth

Teva Investigational Site 10131, Minneapolis

Teva Investigational Site 10175, St Louis

Teva Investigational Site 10189, St Louis

Teva Investigational Site 11147, St Louis

Teva Investigational Site 10118, Bellevue

Teva Investigational Site 10150, Omaha

Teva Investigational Site 11144, Omaha

Teva Investigational Site 11136, Henderson

Teva Investigational Site 10193, Cherry Hill

Teva Investigational Site 10101, Hillsborough

Teva Investigational Site 10114, Laurelton

Teva Investigational Site 10155, Skillman

Teva Investigational Site 10188, West Orange

Teva Investigational Site 11113, Albuquerque

Teva Investigational Site 10187, Brooklyn

Teva Investigational Site 10120, New York

Teva Investigational Site 10190, Newburgh

Teva Investigational Site 10167, North Syracuse

Teva Investigational Site 10112, Rochester

Teva Investigational Site 10105, High Point

Teva Investigational Site 10122, Raleigh

Teva Investigational Site 10194, Canton

Teva Investigational Site 10107, Cincinnati

Teva Investigational Site 10123, Cincinnati

Teva Investigational Site 10144, Columbus

Teva Investigational Site 11135, Dayton

Teva Investigational Site 11115, Middleburg Heights

Teva Investigational Site 10160, Oklahoma City

Teva Investigational Site 10174, Oklahoma City

Teva Investigational Site 10198, Oklahoma City

Teva Investigational Site 11108, Ashland

Teva Investigational Site 10132, Eugene

Teva Investigational Site 10135, Medford

Teva Investigational Site 10142, Portland

Teva Investigational Site 11104, Normal Square

Teva Investigational Site 10183, Philadelphia

Teva Investigational Site 10166, Pittsburgh

Teva Investigational Site 10121, Upland

Teva Investigational Site 11119, East Providence

Teva Investigational Site 10181, Lincoln

Teva Investigational Site 10162, Providence

Teva Investigational Site 10126, Charleston

Teva Investigational Site 10149, Charleston

Teva Investigational Site 10199, Orangeburg

Teva Investigational Site 11131, Spartanburg

Teva Investigational Site 10119, Boerne

Teva Investigational Site 10141, Dallas

Teva Investigational Site 10192, Dallas

Teva Investigational Site 10148, El Paso

Teva Investigational Site 10115, San Antonio

Teva Investigational Site 11133, San Antonio

Teva Investigational Site 11134, San Antonio

Teva Investigational Site 10103, Waco

Teva Investigational Site 11143, Layton

Teva Investigational Site 10195, Provo

Teva Investigational Site 10134, South Burlington

Teva Investigational Site 10159, Burke

Teva Investigational Site 10102, Fairfax

Teva Investigational Site 11105, Manassas

Teva Investigational Site 10108, Richmond

Teva Investigational Site 10124, Spokane

Teva Investigational Site 11117, Tacoma

Teva Investigational Site 11125, Tacoma

Teva Investigational Site 10170, Greenfield

Teva Investigational Site 59107, Burgas

Teva Investigational Site 59103, Lovech

Teva Investigational Site 59106, Pleven

Teva Investigational Site 59104, Rousse

Teva Investigational Site 59101, Sofia

Teva Investigational Site 59102, Sofia

Teva Investigational Site 59105, Sofia

Teva Investigational Site 85105, Split

Teva Investigational Site 85102, Zagreb

Teva Investigational Site 85103, Zagreb

Teva Investigational Site 85104, Zagreb

Teva Investigational Site 36107, Balassagyarmat

Teva Investigational Site 36104, Budapest

Teva Investigational Site 36105, Budapest

Teva Investigational Site 36113, Csoma

Teva Investigational Site 36103, Miskolc

Teva Investigational Site 36108, Mosdós

Teva Investigational Site 36102, Nyíregyháza

Teva Investigational Site 36106, Szeged

Teva Investigational Site 36109, Szeged

Teva Investigational Site 36101, Szombathely

Teva Investigational Site 36111, Tatabánya

Teva Investigational Site 72111, Ashkelon

Teva Investigational Site 72101, Haifa

Teva Investigational Site 72102, Jerusalem

Teva Investigational Site 72104, Jerusalem

Teva Investigational Site 72109, Kfar Saba

Teva Investigational Site 72106, Petah Tikva

Teva Investigational Site 72107, Ramat Gan

Teva Investigational Site 72103, Rehovot

Teva Investigational Site 72108, Tel Aviv

Teva Investigational Site 72110, Tel Aviv

Teva Investigational Site 48107, Bialystok

Teva Investigational Site 48105, Bydgoszcz

Teva Investigational Site 48106, Grodzisk Mazowiecki

Teva Investigational Site 48101, Lodz

Teva Investigational Site 48108, Poznan

Teva Investigational Site 48103, Tarnów

Teva Investigational Site 48104, Wroclaw

Teva Investigational Site 81101, Belgrade

Teva Investigational Site 81102, Belgrade

Teva Investigational Site 34101, Badalona

Teva Investigational Site 34102, Barcelona

Teva Investigational Site 34103, Salt

Teva Investigational Site 80101, Dnipropetrovsk

Teva Investigational Site 80113, Dnipropetrovsk

Teva Investigational Site 80111, Donetsk

Teva Investigational Site 80103, Kharkiv

Teva Investigational Site 80117, Kharkiv

Teva Investigational Site 80104, Kyiv

Teva Investigational Site 80105, Kyiv

Teva Investigational Site 80106, Kyiv

Teva Investigational Site 80107, Kyiv

Teva Investigational Site 80108, Kyiv

Teva Investigational Site 80109, Kyiv

Teva Investigational Site 80114, Odesa

Teva Investigational Site 80118, Ternopil

Teva Investigational Site 80112, Vinnytsia

Teva Investigational Site 80115, Yalta

Teva Investigational Site 80110, Zaporizhzhia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

PPD Development, LP

INDUSTRY

lead

Teva Branded Pharmaceutical Products R&D, Inc.

INDUSTRY