602
Participants
Start Date
January 31, 2013
Primary Completion Date
March 31, 2021
Study Completion Date
March 31, 2021
24-Hour Prophylactic Cefazolin* Antibiotic Regimen
"Pre-Operative Antibiotic Regimen: Patients will receive 2g (or a weight-based dose based on 100mg/kg/day with a maximum single dose of 2g if \< 18 years old) of IV cefazolin within 60 minutes prior to the procedure. No other pre-operative antibiotics will be administered.~Intra-Operative Antibiotic Regimen: Patients will receive 2g (or a weight-based dose based on 100mg/kg/day with a maximum single dose of 2g if \< 18 years old) of IV cefazolin every 3-4 hours. No other intra-operative antibiotics will be administered.~Post-Operative Antibiotic Regimen: Patients will receive 2g (or a weight-based dose based on 100mg/kg/day with a maximum single dose of 2g if \< 18 years old) of IV cefazolin every 8 hours for 24 hours followed by IV saline for 4 days. No other post-operative antibiotics will be administered."
5-Days Prophylactic Cefazolin* Antibiotic Regimen
"Pre-Operative Antibiotic Regimen: Patients will receive 2g (or a weight-based dose based on 100mg/kg/day with a maximum single dose of 2g if \< 18 years old) of IV cefazolin within 60 minutes prior to the procedure. No other pre-operative antibiotics will be administered.~Intra-Operative Antibiotic Regimen: Patients will receive 2g (or a weight-based dose based on 100mg/kg/day with a maximum single dose of 2g if \< 18 years old) of IV cefazolin every 3-4 hours. No other intra-operative antibiotics will be administered.~Post-Operative Antibiotic Regimen: Patients will receive 2g (or a weight-based dose based on 100mg/kg/day with a maximum single dose of 2g if \< 18 years old) of IV cefazolin every 8 hours for 5 days. No other post-operative antibiotics will be administered."
Hospital Universitario Austral, Pilar
Leiden University Medical Center, Leiden
Royal Adelaide Hospital, Adelaide
Memorial Sloan-Kettering Cancer Center, New York
Montefiore Medical Center, The Bronx
Albany Medical Center, Albany
SUNY Upstate University Hospital, East Syracuse
University of Pittsburgh Medical Center, Pittsburgh
The Rothman Institute at Jefferson, Philadelphia
University of Maryland Medical Center, Baltimore
Sinai Hospital of Baltimore, Baltimore
Franklin Square Medical Center, Baltimore
Johns Hopkins Hospital, Baltimore
Emory Orthopaedics and Spine Center, Atlanta
Wexner Medical Center, Columbus
The Cleveland Clinic - Hillcrest Hospital, Cleveland
Cincinnati Children's Hospital, Cincinnati
Holden Comprehensive Cancer Center, Iowa City
Medical College of Wisconsin - Froedtert Hospital, Milwaukee
University of Minnesota Medical Center, Minneapolis
Saint Louis University Hospital, St Louis
University of Arkansas for Medical Sciences, Little Rock
Huntsman Cancer Institute, Salt Lake City
Ronald Reagan UCLA Medical Center, Los Angeles
Stanford University Hospital and Clinics, Redwood City
University of California San Francisco Medical Center, San Francisco
UC Davis Comprehensive Cancer Center, Sacramento
Oregon Health & Science University Hospital, Portland
University of Connecticut Health Center, Farmington
Hartford Hospital, Hartford
University of Florida Health Shands Hospital, Gainesville
Massachusetts General Hospital, Boston
Boston Children's Hospital, Boston
Beth Israel Deaconess Medical Center, Boston
Dartmouth-Hitchcock Medical Center, Lebanon
"Long Island Jewish Medical Center , Northwell Health"
Vanderbilt Medical Center, Nashville
LKH - Universitätsklinikum Graz, Graz
Hospital de Clínicas de Porto Alegre, Porto Alegre
Instituto de Ortopedia e Traumatologia, São Paulo
Children's Cancer Hospital Egypt, Cairo
All India Institute of Medical Sciences, New Delhi
University Medical Center Groningen, Groningen
Singapore General Hospital, Singapore
Grey's Hospital, Pietermaritzburg
Foothills Medical Centre, Calgary
Vancouver General Hospital, Vancouver
Juravinski Hospital and Cancer Centre, Hamilton
Ottawa Hospital, Ottawa
Mount Sinai Hospital, Toronto
Maisonneuve-Rosemont Hospital, Montreal
McGill University Health Centre, Montreal
Hôtel-Dieu de Québec, Québec
Hospital Universitari Vall d'Hebron, Barcelona
Orthopedic Research and Education Foundation
OTHER
The Physicians' Services Incorporated Foundation
OTHER
Canadian Cancer Society (CCS)
OTHER
Canadian Institutes of Health Research (CIHR)
OTHER_GOV
McMaster University
OTHER