Conversion Study From Epoetin Alfa to Monthly Peginesatide Injection in Patients With Chronic Kidney Disease on Dialysis

PHASE3CompletedINTERVENTIONAL
Enrollment

184

Participants

Timeline

Start Date

October 31, 2011

Primary Completion Date

February 28, 2013

Study Completion Date

February 28, 2013

Conditions
Chronic Kidney DiseaseAnemia
Interventions
DRUG

Epoetin

Commercially available epoetin alfa administered weekly, twice weekly, or thrice weekly at an initial starting dose, frequency of administration, and mode of administration (intravenous \[IV\] or subcutaneous \[SC\]) individually determined for each participant using the site's usual standard of care. Subsequent dose adjustments or dose holds may have been made in order to maintain a hemoglobin concentration of \<11 g/dL.

DRUG

Peginesatide

Administered as a once monthly intravenous (IV) or subcutaneous (SC) injection. The initial dose of peginesatide injection was based on the final weekly dose of epoetin administered in the SCP; subsequent doses may have been adjusted in order to maintain hemoglobin concentrations at \<11 g/dL.

Trial Locations (5)

78215

Research Facility, San Antonio

91910

Research Facility, San Diego

95128

Research Facility, San Jose

95825

Research Facility, Sacramento

08902

Research Facility, North Brunswick

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Affymax

INDUSTRY

lead

Takeda

INDUSTRY