A Study Combining mFOLFOX6 With Tivozanib or Bevacizumab in Patients With Metastatic Colorectal Cancer as First Line Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

265

Participants

Timeline

Start Date

December 31, 2011

Primary Completion Date

September 30, 2013

Study Completion Date

January 31, 2015

Conditions
Colorectal Cancer
Interventions
DRUG

Tivozanib

Capsules for oral administration

DRUG

Bevacizumab

Solution for intravenous infusion

DRUG

mFOLFOX6

mFOLFOX6 regimen is a combination therapy of oxaliplatin 85 mg/m\^2 administered as an intravenous bolus over 2 hours on Days 1 and 15, leucovorin calcium 400 mg/m\^2 administered as an intravenous bolus over 2 hours on Days 1 and 15, fluorouracil 400 mg/m\^2 administered as an intravenous bolus over 5 to 15 minutes on Days 1 and 15, then 2400 mg/m\^2 continuous intravenous infusion over 46 hours on Days 1 to 3 and 15 to 17.

Trial Locations (73)

1122

Orszagos Onkologiai Intezet, Budapest

2020

Ziekenhuisnetwerk Antwerpen - AZ Middelheim, Antwerp

2217

St George Hospital, Kogarah

2298

Calvary Mater Newcastle, Waratah

2485

Tweed Hospital, Tweed Heads

2820

Imelda VZW, Bonheiden

3144

Cabrini Hospital Malvern, Malvern

3350

Ballarat Health Services, Ballarat

3690

Border Medical Oncology, Wodonga

4600

Klinikum Wels-Grieskirchen GmbH, Wels

5020

Salzburger Landesklinken, Salzburg

5042

Flinders Medical Centre, Bedford Park

5700

Bekes Megyei Kepviselotestulet Pandy Kalman Korhaza, Gyula

7000

Royal Hobart Hospital, Hobart

8000

Fejer Megyei Szent Gyorgy Korhaz, Székesfehérvár

8036

Medizinische Universitat Graz, Graz

8310

AZ Sint-Lucas Brugge, Bruges

8500

AZ Groeninge - Campus Sint-Niklaas, Kortrijk

9024

Petz Aladar Megyei Oktato Korhaz, Győr

10016

NYU Cancer Institute, New York

10060

Fondazione del Piemonte per I'Oncologia IRCC, Candiolo

15009

Centro Oncologico de Galicia, Galicia

16132

IRCCS Azienda Ospedaliera Universitaria San Martino - Istituto Nazionale per la Ricerca sul Cancro, Genova

18015

Oncology Hematology of Lehigh Valley, Bethlehem

20089

Istituto Clinico Humanitas, Rozzano (MI)

20850

Associates of Oncology Hematology, P.C., Rockville

27215

Alamance Regional Medical Center, Burlington

28050

Centro Integral Oncologico Clara Campal, Madrid

32610

University of Florida, Davis Cancer Center (VA), Gainesville

33331

Cleveland Clinic Florida, Weston

39008

Hospital Universitario Marques de Valdecilla, Santander

40128

Azienda Ospedaliero- Universitaria di Bologna - Policlinico S.Orsola-Malpighi, Bologna

44718

Tri Country Hematology / Oncology, Canton

45042

Signal Point Clinical Research Center, LLC, Middletown

46260

Investigative Clinical Research of Indiana, LLC, Indianapolis

47905

Horizon Oncology Research, Inc., Lafayette

48109

University of Michigan Health, Ann Arbor

50009

Hospital Universitario Miguel Servet, Zaragoza

60611

Northwestern University, Chicago

61615

Illinios Cancer Care, Peoria

71913

Genesis Cancer Center, Hot Springs

74136

Cancer Care Associates, Tulsa

80033

Mountain Blue Cancer Care Center, Golden

84403

Northern Utah Associates, Ogden

85234

Banner MD Anderson Cancer Research Center, Gilbert

85715

Arizona Clinical Research Center, Tucson

92093

University of California San Diego-Morris Cancer Center, La Jolla

92270

Desert Hematology Oncology Medical Group, Inc., Rancho Mirage

92868

UC Irvine Medical Center, Division of Hematology/Oncology, Orange

96813

Queen's Medical Center, Honolulu

University of Hawaii, Honolulu

96819

Kaiser Foundation Hospitals, Honolulu

97239

Oregon Health and Science University, Portland

98109

Seattle Cancer Care Alliance, Seattle

V5Z 4E6

British Columbia Cancer Agency, Vancouver

B3H 2Y9

QEII Health Science Centre, Halifax

H7M 3L9

Hopital De La Cite-De-La-Sante, Laval

H2X 3J4

Hopital Saint-Luc - Pavillon Principal, Montreal

G1R 2J6

Chuq Centre Hospitalier Universitaire De Quebec, Québec

656 53

Masarykuv onkologicky ustav, Brno

500 05

Fakultni nemocnice Hradec Kralove, Hradec Králové

FI-33520

Tampereen yliopistollinen sairaala, Tampere

FI-20520

Turun yliopistollinen keskussairaala, Turku

4819 EV

Amphia Ziekenhuis, Breda

08208

Corporacio Sanitaria Parc Tauli, Sabadell

08221

Hospital Mutua de Terrassa, Terrassa

CB2 2QQ

Addenbrooke's Hospital, Cambridge

EH4 2XU

Western General Hospital, Edinburgh

G12 0YN

Beatson West of Scotland Cancer Center, Glasgow

NW1 2BU

University College Hospital, London

ME16 9QQ

Maidstone Hospital, Maidstone

M20 4BX

Christie Hospital, Manchester

PE3 6DA

Peterborough and Stamford Hospitals NHS Foundation Trust, Peterborough

Sponsors
All Listed Sponsors
lead

AVEO Pharmaceuticals, Inc.

INDUSTRY